Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964812946> ?p ?o ?g. }
- W1964812946 endingPage "1460" @default.
- W1964812946 startingPage "1455" @default.
- W1964812946 abstract "Hemoglobin adducts are often used as biomarkers for exposure to reactive chemicals in toxicology studies. Therefore, fast, sensitive, accurate, and reproducible methods for quantifying these protein adducts are key to evaluate test material dosimetry. A methodology has been developed for the quantitation of methylated hemoglobin adducts isolated from rats exposed to the model alkylating agent: methyl methane sulfonate (MMS). After 4 days of MMS exposure by oral gavage, hemoglobin was isolated from rat blood and digested with trypsin. The tryptic digestion solution was used for the adducted hemoglobin signature peptide quantitation via liquid chromatography/negative tandem mass spectrometry (LC/ESI-MS/MS). The limit of quantitation (LOQ) for the methylated hemoglobin beta chain N-terminal signature peptide (MeVHLTDAEK) was 1.95 ng/mL (5.9 pmol/mg globin). The calibration curves were linear over a concentration range of 1.95 to 625 ng/mL, with a correlation coefficient R2 >0.998, accuracy of 85.8 to 119.3%, and precision of 0.9 to 19.4%. Copyright © 2008 John Wiley & Sons, Ltd." @default.
- W1964812946 created "2016-06-24" @default.
- W1964812946 creator A5001452107 @default.
- W1964812946 creator A5005064979 @default.
- W1964812946 creator A5038916027 @default.
- W1964812946 creator A5043988858 @default.
- W1964812946 creator A5046466699 @default.
- W1964812946 creator A5051491025 @default.
- W1964812946 date "2008-01-01" @default.
- W1964812946 modified "2023-09-24" @default.
- W1964812946 title "Quantitation of methylated hemoglobin adducts in a signature peptide from rat blood by liquid chromatography/negative electrospray ionization tandem mass spectrometry" @default.
- W1964812946 cites W151774759 @default.
- W1964812946 cites W1857678831 @default.
- W1964812946 cites W1902586882 @default.
- W1964812946 cites W1966945007 @default.
- W1964812946 cites W1968058930 @default.
- W1964812946 cites W1972080189 @default.
- W1964812946 cites W1972600929 @default.
- W1964812946 cites W1981454032 @default.
- W1964812946 cites W1987580232 @default.
- W1964812946 cites W2001228696 @default.
- W1964812946 cites W2002976054 @default.
- W1964812946 cites W2004842367 @default.
- W1964812946 cites W2006296876 @default.
- W1964812946 cites W2006364161 @default.
- W1964812946 cites W2018883841 @default.
- W1964812946 cites W2024724004 @default.
- W1964812946 cites W2026144448 @default.
- W1964812946 cites W2030998684 @default.
- W1964812946 cites W2056893465 @default.
- W1964812946 cites W2062379350 @default.
- W1964812946 cites W2063487279 @default.
- W1964812946 cites W2064668525 @default.
- W1964812946 cites W2065739296 @default.
- W1964812946 cites W2072083287 @default.
- W1964812946 cites W2088281147 @default.
- W1964812946 cites W2088920392 @default.
- W1964812946 cites W2101683626 @default.
- W1964812946 cites W2102761334 @default.
- W1964812946 cites W2104581629 @default.
- W1964812946 cites W2104967314 @default.
- W1964812946 cites W2134940081 @default.
- W1964812946 cites W2148307643 @default.
- W1964812946 cites W2151799558 @default.
- W1964812946 cites W2171693081 @default.
- W1964812946 cites W2324375972 @default.
- W1964812946 cites W2129490525 @default.
- W1964812946 doi "https://doi.org/10.1002/rcm.3530" @default.
- W1964812946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18398826" @default.
- W1964812946 hasPublicationYear "2008" @default.
- W1964812946 type Work @default.
- W1964812946 sameAs 1964812946 @default.
- W1964812946 citedByCount "9" @default.
- W1964812946 countsByYear W19648129462012 @default.
- W1964812946 countsByYear W19648129462014 @default.
- W1964812946 countsByYear W19648129462015 @default.
- W1964812946 countsByYear W19648129462016 @default.
- W1964812946 countsByYear W19648129462017 @default.
- W1964812946 crossrefType "journal-article" @default.
- W1964812946 hasAuthorship W1964812946A5001452107 @default.
- W1964812946 hasAuthorship W1964812946A5005064979 @default.
- W1964812946 hasAuthorship W1964812946A5038916027 @default.
- W1964812946 hasAuthorship W1964812946A5043988858 @default.
- W1964812946 hasAuthorship W1964812946A5046466699 @default.
- W1964812946 hasAuthorship W1964812946A5051491025 @default.
- W1964812946 hasConcept C108204754 @default.
- W1964812946 hasConcept C119128265 @default.
- W1964812946 hasConcept C125996951 @default.
- W1964812946 hasConcept C162356407 @default.
- W1964812946 hasConcept C178790620 @default.
- W1964812946 hasConcept C185592680 @default.
- W1964812946 hasConcept C2778917026 @default.
- W1964812946 hasConcept C2779281246 @default.
- W1964812946 hasConcept C31827203 @default.
- W1964812946 hasConcept C40684141 @default.
- W1964812946 hasConcept C43617362 @default.
- W1964812946 hasConcept C55493867 @default.
- W1964812946 hasConcept C64489805 @default.
- W1964812946 hasConcept C71043704 @default.
- W1964812946 hasConceptScore W1964812946C108204754 @default.
- W1964812946 hasConceptScore W1964812946C119128265 @default.
- W1964812946 hasConceptScore W1964812946C125996951 @default.
- W1964812946 hasConceptScore W1964812946C162356407 @default.
- W1964812946 hasConceptScore W1964812946C178790620 @default.
- W1964812946 hasConceptScore W1964812946C185592680 @default.
- W1964812946 hasConceptScore W1964812946C2778917026 @default.
- W1964812946 hasConceptScore W1964812946C2779281246 @default.
- W1964812946 hasConceptScore W1964812946C31827203 @default.
- W1964812946 hasConceptScore W1964812946C40684141 @default.
- W1964812946 hasConceptScore W1964812946C43617362 @default.
- W1964812946 hasConceptScore W1964812946C55493867 @default.
- W1964812946 hasConceptScore W1964812946C64489805 @default.
- W1964812946 hasConceptScore W1964812946C71043704 @default.
- W1964812946 hasIssue "10" @default.
- W1964812946 hasLocation W19648129461 @default.
- W1964812946 hasLocation W19648129462 @default.
- W1964812946 hasOpenAccess W1964812946 @default.
- W1964812946 hasPrimaryLocation W19648129461 @default.