Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964814271> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1964814271 endingPage "276" @default.
- W1964814271 startingPage "267" @default.
- W1964814271 abstract "24-Hydroxylated derivatives were synthesized in 24(R) and 24(S) forms by the convergent method as analogs related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3. In the convergent synthesis, the A-ring fragment, synthesized from diethyl D-tartarate, and the C/D-ring fragments in 24(R) and 24(S) forms (vitamin D numbering), obtained from vitamin D2 via the Inhoffen-Lythgoe diol, were coupled in moderate yields to give 1α,24(R),25-trihydroxy-2β-(3-hydroxypropoxy)vitamin D3 and 1α,24(S),25-trihydroxy-2β-(3-hydroxypropoxy)vitamin D3. In preliminary biological evaluations, 24-hydroxylation of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 caused weakened affinity to vitamin D binding protein in vitro and less calcemic activity in vivo compared to the parent compound. While the affinity to vitamin D receptor in 24(R) epimer was sustained, the affinity in 24(S) epimer was less than that of the parent compound." @default.
- W1964814271 created "2016-06-24" @default.
- W1964814271 creator A5016243867 @default.
- W1964814271 creator A5023449950 @default.
- W1964814271 creator A5024954196 @default.
- W1964814271 creator A5062220638 @default.
- W1964814271 creator A5068374303 @default.
- W1964814271 creator A5085285484 @default.
- W1964814271 date "2001-03-01" @default.
- W1964814271 modified "2023-10-05" @default.
- W1964814271 title "Synthesis and biological characterization of 1α,24,25-trihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (24-hydroxylated ED-71)" @default.
- W1964814271 cites W1972319047 @default.
- W1964814271 cites W1981109256 @default.
- W1964814271 cites W1999327997 @default.
- W1964814271 cites W2002237621 @default.
- W1964814271 cites W2014444933 @default.
- W1964814271 cites W2035966343 @default.
- W1964814271 cites W2042049058 @default.
- W1964814271 cites W2046175339 @default.
- W1964814271 cites W2068476087 @default.
- W1964814271 cites W2088847197 @default.
- W1964814271 cites W2094514334 @default.
- W1964814271 cites W2095531504 @default.
- W1964814271 cites W2327391798 @default.
- W1964814271 cites W233628489 @default.
- W1964814271 cites W2949262009 @default.
- W1964814271 cites W2950291698 @default.
- W1964814271 cites W2952111146 @default.
- W1964814271 doi "https://doi.org/10.1016/s0039-128x(00)00149-5" @default.
- W1964814271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11179734" @default.
- W1964814271 hasPublicationYear "2001" @default.
- W1964814271 type Work @default.
- W1964814271 sameAs 1964814271 @default.
- W1964814271 citedByCount "20" @default.
- W1964814271 countsByYear W19648142712014 @default.
- W1964814271 countsByYear W19648142712015 @default.
- W1964814271 countsByYear W19648142712016 @default.
- W1964814271 countsByYear W19648142712017 @default.
- W1964814271 countsByYear W19648142712018 @default.
- W1964814271 countsByYear W19648142712020 @default.
- W1964814271 countsByYear W19648142712022 @default.
- W1964814271 countsByYear W19648142712023 @default.
- W1964814271 crossrefType "journal-article" @default.
- W1964814271 hasAuthorship W1964814271A5016243867 @default.
- W1964814271 hasAuthorship W1964814271A5023449950 @default.
- W1964814271 hasAuthorship W1964814271A5024954196 @default.
- W1964814271 hasAuthorship W1964814271A5062220638 @default.
- W1964814271 hasAuthorship W1964814271A5068374303 @default.
- W1964814271 hasAuthorship W1964814271A5085285484 @default.
- W1964814271 hasConcept C116073593 @default.
- W1964814271 hasConcept C178790620 @default.
- W1964814271 hasConcept C181199279 @default.
- W1964814271 hasConcept C185592680 @default.
- W1964814271 hasConcept C202751555 @default.
- W1964814271 hasConcept C203130289 @default.
- W1964814271 hasConcept C2776940978 @default.
- W1964814271 hasConcept C2780378348 @default.
- W1964814271 hasConcept C2781109383 @default.
- W1964814271 hasConcept C55493867 @default.
- W1964814271 hasConcept C71240020 @default.
- W1964814271 hasConceptScore W1964814271C116073593 @default.
- W1964814271 hasConceptScore W1964814271C178790620 @default.
- W1964814271 hasConceptScore W1964814271C181199279 @default.
- W1964814271 hasConceptScore W1964814271C185592680 @default.
- W1964814271 hasConceptScore W1964814271C202751555 @default.
- W1964814271 hasConceptScore W1964814271C203130289 @default.
- W1964814271 hasConceptScore W1964814271C2776940978 @default.
- W1964814271 hasConceptScore W1964814271C2780378348 @default.
- W1964814271 hasConceptScore W1964814271C2781109383 @default.
- W1964814271 hasConceptScore W1964814271C55493867 @default.
- W1964814271 hasConceptScore W1964814271C71240020 @default.
- W1964814271 hasIssue "3-5" @default.
- W1964814271 hasLocation W19648142711 @default.
- W1964814271 hasLocation W19648142712 @default.
- W1964814271 hasOpenAccess W1964814271 @default.
- W1964814271 hasPrimaryLocation W19648142711 @default.
- W1964814271 hasRelatedWork W1032940004 @default.
- W1964814271 hasRelatedWork W1964814271 @default.
- W1964814271 hasRelatedWork W1971324412 @default.
- W1964814271 hasRelatedWork W1975278455 @default.
- W1964814271 hasRelatedWork W1998662807 @default.
- W1964814271 hasRelatedWork W1998815983 @default.
- W1964814271 hasRelatedWork W2061751884 @default.
- W1964814271 hasRelatedWork W2063082353 @default.
- W1964814271 hasRelatedWork W2318276571 @default.
- W1964814271 hasRelatedWork W2341605098 @default.
- W1964814271 hasVolume "66" @default.
- W1964814271 isParatext "false" @default.
- W1964814271 isRetracted "false" @default.
- W1964814271 magId "1964814271" @default.
- W1964814271 workType "article" @default.