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• W1964821887 abstract "2-thio-3-aryl quinazolin-4(3H)one (1) was synthesized by reacting anthranilic acid with thiocarbamate salts of substituted aniline and carbon disulphide, which on reflux with excess of hydrazine hydrate to form 2-hydrazino quinazolin-4(3H)one derivatives (2). The reaction of (2) with variously substituted aryl aldehydes gave the corresponding hydrazones (3). Further, the cyclization of compound (3) in acetic anhydride gave tricyclic pyrazoloquinazolinones (4). All newly synthesized compounds have been tested for their antibacterial activity against gram +ve bacteria B. substilis, S. aureus and gram -ve bacteria E. coli, P. vulgaris. The species used for antifungal activity are Aspergillus niger and Phytophora. Introduction of -OCH3, -OH and -Cl groups to the heterocyclic frame work enhanced antibacterial and antifungal activities." @default.
• W1964821887 created "2016-06-24" @default.
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• W1964821887 date "2010-01-01" @default.
• W1964821887 modified "2023-09-26" @default.
• W1964821887 title "Synthesis and antimicrobial screening of pyrazolo-3-aryl quinazolin-4(3h)ones" @default.
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• W1964821887 doi "https://doi.org/10.4103/0250-474x.73934" @default.
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