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- W1964829412 abstract "We have investigatedCFTRspecific intestinal expression by transfection assays in mouse cultured fibroblasts and transimmortalized intestinal crypt m-ICcl2cells using the β-galactosidase gene linked to ratCFTRnon-coding regions. Two constructs were studied, one encompassing a 5.3 kb region 5′ to the gene where numerous duodenum-specific DNase I hypersensitive sites (DHSs) were previously mapped and the other including a 1.3 kb 3′ region in which novel DHSs had been identified. In transient transfection assays, transgenes were expressed in m-ICcl2cells but not in fibroblasts. In m-ICcl2cells, the pattern of expression of the chromosomally integrated transgenes paralleled the endogenous expression ofCFTRand β-galactosidase activity was detected in cells containing villin and forming domes. Thus, a 6.6 kb region encompassing 5′ and 3′ non-coding parts of ratCFTRis able to drive specific expression of a reporter gene in cultured mouse intestinal cells having kept a crypt phenotype." @default.
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- W1964829412 date "1998-09-01" @default.
- W1964829412 modified "2023-09-27" @default.
- W1964829412 title "CFTRRegions Containing Duodenum Specific DNase I Hypersensitive Sites Drive Expression in Intestinal Crypt Cells but Not in Fibroblasts" @default.
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- W1964829412 doi "https://doi.org/10.1006/bbrc.1998.9292" @default.
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