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• W1964838077 startingPage "433" @default.
• W1964838077 abstract "Docosahexaenoic acid (DHA) is an indispensable component of cell membranes that is required at high levels during pregnancy.We investigated the effects of DHA (0 to 100 microM) in the placenta on oxidative stress using a trophoblast cell line, BeWo.Oxidative stress levels (as evaluated using a fluorescent probe) and lipid peroxidation were significantly higher in cells preincubated with 100 microM of DHA. Oxidative DNA damage in cells preincubated with modest levels of DHA (1 or 10 microM) was significantly lower than for untreated cells or cells preincubated with 100 microM DHA. Survival rates of cells preincubated with modest levels of DHA after oxidative challenge (with H(2)O(2) or Xanthine plus Xanthine oxidase) were significantly higher than without DHA preincubation.Modest levels of DHA alleviate oxidative DNA damage whereas high levels of DHA accelerate lipid peroxidation. Thus, DHA supplementation during pregnancy may exert oxidative or antioxidant properties via different mechanisms and depending on dosage." @default.
• W1964838077 created "2016-06-24" @default.
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• W1964838077 creator A5040277439 @default.
• W1964838077 creator A5087618628 @default.
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• W1964838077 date "2009-07-01" @default.
• W1964838077 modified "2023-09-26" @default.
• W1964838077 title "Effect of docosahexaenoic acid on oxidative stress in placental trophoblast cells" @default.
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• W1964838077 doi "https://doi.org/10.1016/j.earlhumdev.2009.02.003" @default.
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