FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964845139> ?p ?o ?g. }

• W1964845139 endingPage "347" @default.
• W1964845139 startingPage "336" @default.
• W1964845139 abstract "Lymphatic vessels play an important role in tissue fluid homeostasis, intestinal fat absorption and immunosurveillance. Furthermore, they are involved in pathologic conditions, such as tumor cell metastasis and chronic inflammation. In comparison to blood vessels, the molecular phenotype of lymphatic vessels is less well characterized. Performing comparative gene expression analysis we have recently found that coxsackie- and adenovirus receptor (CAR) is significantly more highly expressed in cultured human, skin-derived lymphatic endothelial cells (LECs), as compared to blood vascular endothelial cells. Here, we have confirmed these results at the protein level, using Western blot and FACS analysis. Immunofluorescence performed on human skin confirmed that CAR is expressed at detectable levels in lymphatic vessels, but not in blood vessels. To address the functional significance of CAR expression, we modulated CAR expression levels in cultured LECs in vitro by siRNA- and vector-based transfection approaches. Functional assays performed with the transfected cells revealed that CAR is involved in distinct cellular processes in LECs, such as cell adhesion, migration, tube formation and the control of vascular permeability. In contrast, no effect of CAR on LEC proliferation was observed. Overall, our data suggest that CAR stabilizes LEC–LEC interactions in the skin and may contribute to lymphatic vessel integrity." @default.
• W1964845139 created "2016-06-24" @default.
• W1964845139 creator A5029377984 @default.
• W1964845139 creator A5039749957 @default.
• W1964845139 creator A5039926073 @default.
• W1964845139 creator A5054005843 @default.
• W1964845139 creator A5054443631 @default.
• W1964845139 creator A5060019261 @default.
• W1964845139 date "2009-01-01" @default.
• W1964845139 modified "2023-10-16" @default.
• W1964845139 title "Coxsackie- and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro" @default.
• W1964845139 cites W1519030262 @default.
• W1964845139 cites W1574424832 @default.
• W1964845139 cites W1905871585 @default.
• W1964845139 cites W1963910714 @default.
• W1964845139 cites W1992101966 @default.
• W1964845139 cites W1993066851 @default.
• W1964845139 cites W1994018086 @default.
• W1964845139 cites W1994638693 @default.
• W1964845139 cites W2005127084 @default.
• W1964845139 cites W2006043434 @default.
• W1964845139 cites W2006202262 @default.
• W1964845139 cites W2006642493 @default.
• W1964845139 cites W2006792093 @default.
• W1964845139 cites W2017311183 @default.
• W1964845139 cites W2019259556 @default.
• W1964845139 cites W2019745410 @default.
• W1964845139 cites W2027213473 @default.
• W1964845139 cites W2030837990 @default.
• W1964845139 cites W2031068361 @default.
• W1964845139 cites W2037380046 @default.
• W1964845139 cites W2039217577 @default.
• W1964845139 cites W2046513138 @default.
• W1964845139 cites W2047724121 @default.
• W1964845139 cites W2048142299 @default.
• W1964845139 cites W2049018391 @default.
• W1964845139 cites W2049889887 @default.
• W1964845139 cites W2050015911 @default.
• W1964845139 cites W2050286843 @default.
• W1964845139 cites W2058014017 @default.
• W1964845139 cites W2072603494 @default.
• W1964845139 cites W2072889522 @default.
• W1964845139 cites W2074190587 @default.
• W1964845139 cites W2087962991 @default.
• W1964845139 cites W2088830438 @default.
• W1964845139 cites W2092623873 @default.
• W1964845139 cites W2096418924 @default.
• W1964845139 cites W2102374546 @default.
• W1964845139 cites W2125263061 @default.
• W1964845139 cites W2125621940 @default.
• W1964845139 cites W2129081579 @default.
• W1964845139 cites W2144451242 @default.
• W1964845139 cites W2156262303 @default.
• W1964845139 cites W2158484702 @default.
• W1964845139 cites W2158659385 @default.
• W1964845139 cites W2163380226 @default.
• W1964845139 cites W4230026896 @default.
• W1964845139 doi "https://doi.org/10.1016/j.yexcr.2008.10.020" @default.
• W1964845139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19007771" @default.
• W1964845139 hasPublicationYear "2009" @default.
• W1964845139 type Work @default.
• W1964845139 sameAs 1964845139 @default.
• W1964845139 citedByCount "29" @default.
• W1964845139 countsByYear W19648451392012 @default.
• W1964845139 countsByYear W19648451392013 @default.
• W1964845139 countsByYear W19648451392014 @default.
• W1964845139 countsByYear W19648451392015 @default.
• W1964845139 countsByYear W19648451392016 @default.
• W1964845139 countsByYear W19648451392017 @default.
• W1964845139 countsByYear W19648451392019 @default.
• W1964845139 countsByYear W19648451392020 @default.
• W1964845139 countsByYear W19648451392023 @default.
• W1964845139 crossrefType "journal-article" @default.
• W1964845139 hasAuthorship W1964845139A5029377984 @default.
• W1964845139 hasAuthorship W1964845139A5039749957 @default.
• W1964845139 hasAuthorship W1964845139A5039926073 @default.
• W1964845139 hasAuthorship W1964845139A5054005843 @default.
• W1964845139 hasAuthorship W1964845139A5054443631 @default.
• W1964845139 hasAuthorship W1964845139A5060019261 @default.
• W1964845139 hasConcept C121608353 @default.
• W1964845139 hasConcept C123012128 @default.
• W1964845139 hasConcept C142724271 @default.
• W1964845139 hasConcept C159654299 @default.
• W1964845139 hasConcept C181152851 @default.
• W1964845139 hasConcept C202751555 @default.
• W1964845139 hasConcept C203014093 @default.
• W1964845139 hasConcept C2776636583 @default.
• W1964845139 hasConcept C2778236600 @default.
• W1964845139 hasConcept C2779013556 @default.
• W1964845139 hasConcept C2780965494 @default.
• W1964845139 hasConcept C2910366181 @default.
• W1964845139 hasConcept C54009773 @default.
• W1964845139 hasConcept C54355233 @default.
• W1964845139 hasConcept C55493867 @default.
• W1964845139 hasConcept C71924100 @default.
• W1964845139 hasConcept C81885089 @default.
• W1964845139 hasConcept C86803240 @default.
• W1964845139 hasConcept C95444343 @default.

• next