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- W1964851255 abstract "The prevailing neurocircuitry models of anxiety disorders have been amygdalocentric in form. The bases for such models have progressed from theoretical considerations, extrapolated from research in animals, to in vivo human imaging data. For example, one current model of posttraumatic stress disorder (PTSD) has been highly influenced by knowledge from rodent fear conditioning research. Given the phenomenological parallels between fear conditioning and the pathogenesis of PTSD, we have proposed that PTSD is characterized by exaggerated amygdala responses (subserving exaggerated acquisition of fear associations and expression of fear responses) and deficient frontal cortical function (mediating deficits in extinction and the capacity to suppress attention/response to trauma-related stimuli), as well as deficient hippocampal function (mediating deficits in appreciation of safe contexts and explicit learning/memory). Neuroimaging studies have yielded convergent findings in support of this model. However, to date, neuroimaging investigations of PTSD have not principally employed conditioning and extinction paradigms per se. The recent development of such imaging probes now sets the stage for directly testing hypotheses regarding the neural substrates of fear conditioning and extinction abnormalities in PTSD." @default.
- W1964851255 created "2016-06-24" @default.
- W1964851255 creator A5003508601 @default.
- W1964851255 creator A5015892598 @default.
- W1964851255 creator A5090123241 @default.
- W1964851255 date "2006-08-01" @default.
- W1964851255 modified "2023-10-11" @default.
- W1964851255 title "Neurocircuitry Models of Posttraumatic Stress Disorder and Extinction: Human Neuroimaging Research—Past, Present, and Future" @default.
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- W1964851255 doi "https://doi.org/10.1016/j.biopsych.2006.06.004" @default.
- W1964851255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16919525" @default.
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