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- W1964857548 abstract "Several brain areas modulate pain transmission through direct projections to the spinal cord. The descending modulation is exerted by neurotransmitters acting both at spinally projecting neurons and at interneurons that target the projection neurons. We analyzed the expression of μ-opioid (MOR), γ-aminobutyric acid GABAB, and NK1 receptors in spinally projecting neurons of major medullary pain control areas of the rat: rostroventromedial medulla (RVM), dorsal reticular nucleus (DRt), nucleus of the solitary tract, ventral reticular nucleus, and lateralmost part of the caudal ventrolateral medulla. The retrograde tracer cholera toxin subunit B (CTb) was injected into the spinal dorsal horn, and medullary sections were processed by double immunocytochemistry for CTb and each receptor. The RVM contained the majority of double-labeled neurons followed by the DRt. In general, high percentages of MOR- and NK1-expressing neurons were retrogradely labeled, whereas GABAB receptors were mainly expressed in neurons that were not labeled from the cord. The results suggest that MOR and NK1 receptors play an important role in direct and indirect control of descending modulation. The co-localization of MOR and GABAB in DRt neurons also demonstrated by the present study suggests that the pronociceptive effects of this nucleus may be controlled by local opoidergic and GABAergic inhibition of the pronociception increased during chronic pain. J. Comp. Neurol. 510:175–187, 2008. © 2008 Wiley-Liss, Inc." @default.
- W1964857548 created "2016-06-24" @default.
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- W1964857548 date "2008-09-10" @default.
- W1964857548 modified "2023-10-17" @default.
- W1964857548 title "Participation of μ-opioid, GABA<sub>B</sub>, and NK1 receptors of major pain control medullary areas in pathways targeting the rat spinal cord: Implications for descending modulation of nociceptive transmission" @default.
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- W1964857548 doi "https://doi.org/10.1002/cne.21793" @default.
- W1964857548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18615498" @default.
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