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- W1964861862 abstract "<h2>Abstract</h2> To characterize the nature of the α chain of TCR associated with the development of experimental autoimmune encephalomyelitis (EAE), spinal cord T cells isolated from individual rats with preclinical and clinical EAE were investigated by CDR3 spectratyping and subsequently, the amino acid sequences of the CDR3 region of oligoclonally expanded TCR determined. In contrast to the β chain repertoire in which Vβ8.2 with the shortest CDR3 is the predominant population throughout the course, multiple oligoclonal expansion was observed at all time points examined. Characteristically, Vα1 and Vα2 expansion was observed at preclinical and early stages, whereas that of Vα8, Vα13 and Vα23 was detected at early and peak stages. Sequence analysis of the CDR3 region revealed that the former group possessed an asparagine repeat in the middle portion, whereas the latter group had the KLTF motif in the C terminal region of CDR3. These findings suggest that Vα usage by EAE-associated T cells is stage-dependent and that EAE is induced by polyclonally activated T cells which switch TCR α chain, but not β chain, phenotype as the disease progresses." @default.
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- W1964861862 date "1999-04-01" @default.
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- W1964861862 title "Stage-dependent usage of TCR α chains with different CDR3 motifs by spinal cord T cells in autoimmune encephalomyelitis" @default.
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- W1964861862 doi "https://doi.org/10.1016/s0165-5728(99)00016-8" @default.
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