FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964875700> ?p ?o ?g. }

• W1964875700 endingPage "615" @default.
• W1964875700 startingPage "609" @default.
• W1964875700 abstract "Mucosal macrophages have been implicated in the pathogenesis of inflammatory bowel disease (IBD). Macrophage-colony stimulating factor (M-CSF) influences monocyte/macrophage proliferation, differentiation, and activation. Serum levels are increased in active IBD, but little is known about its role in mucosal inflammation. This study was undertaken to determine the distribution, frequency, and level of M-CSF expression in normal and IBD-affected intestine. RNA and tissue were studied from patients with Crohn's disease (CD) and ulcerative colitis (UC) as well as from histologically normal colon. Tissue from intestinal tuberculosis and ischaemic colitis patients served as controls. M-CSF mRNA and protein were examined by semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), in situ hybridisation, and immunohistochemistry, respectively. M-CSF mRNA and protein were detected in histologically normal intestine, but their expression was largely confined to the mucosa. In active IBD, the frequency of M-CSF-expressing cells was significantly increased and their distribution markedly altered, although no increase in mucosal M-CSF mRNA levels in intestinal tissue was observed. The changes were not specific to IBD, as there were similar findings in intestinal tuberculosis and ischaemic colitis. The marked alteration observed in M-CSF expression in IBD and the importance of this cytokine in stimulating macrophage functions suggest that M-CSF may contribute to the pathogenesis of the IBD lesion." @default.
• W1964875700 created "2016-06-24" @default.
• W1964875700 creator A5025274207 @default.
• W1964875700 creator A5041065733 @default.
• W1964875700 creator A5066013141 @default.
• W1964875700 creator A5074279833 @default.
• W1964875700 date "2001-01-01" @default.
• W1964875700 modified "2023-09-23" @default.
• W1964875700 title "Expression of macrophage-colony stimulating factor in normal and inflammatory bowel disease intestine" @default.
• W1964875700 cites W109207037 @default.
• W1964875700 cites W1270370721 @default.
• W1964875700 cites W1531075790 @default.
• W1964875700 cites W1550691023 @default.
• W1964875700 cites W1585484045 @default.
• W1964875700 cites W1587324932 @default.
• W1964875700 cites W1595995853 @default.
• W1964875700 cites W1654230491 @default.
• W1964875700 cites W1970157987 @default.
• W1964875700 cites W1972987064 @default.
• W1964875700 cites W1982662087 @default.
• W1964875700 cites W2017356863 @default.
• W1964875700 cites W2022122015 @default.
• W1964875700 cites W2025732397 @default.
• W1964875700 cites W2026644950 @default.
• W1964875700 cites W2045267433 @default.
• W1964875700 cites W2048659444 @default.
• W1964875700 cites W2057416951 @default.
• W1964875700 cites W2070111160 @default.
• W1964875700 cites W2074260855 @default.
• W1964875700 cites W2078019320 @default.
• W1964875700 cites W2104200433 @default.
• W1964875700 cites W2104678674 @default.
• W1964875700 cites W2133351125 @default.
• W1964875700 cites W2163179265 @default.
• W1964875700 cites W2187834348 @default.
• W1964875700 cites W2316810802 @default.
• W1964875700 cites W2416051049 @default.
• W1964875700 cites W4236389138 @default.
• W1964875700 cites W4244798840 @default.
• W1964875700 cites W4294216491 @default.
• W1964875700 cites W71036867 @default.
• W1964875700 doi "https://doi.org/10.1002/path.991" @default.
• W1964875700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11745698" @default.
• W1964875700 hasPublicationYear "2001" @default.
• W1964875700 type Work @default.
• W1964875700 sameAs 1964875700 @default.
• W1964875700 citedByCount "39" @default.
• W1964875700 countsByYear W19648757002012 @default.
• W1964875700 countsByYear W19648757002014 @default.
• W1964875700 countsByYear W19648757002015 @default.
• W1964875700 countsByYear W19648757002017 @default.
• W1964875700 countsByYear W19648757002018 @default.
• W1964875700 countsByYear W19648757002020 @default.
• W1964875700 countsByYear W19648757002021 @default.
• W1964875700 countsByYear W19648757002022 @default.
• W1964875700 countsByYear W19648757002023 @default.
• W1964875700 crossrefType "journal-article" @default.
• W1964875700 hasAuthorship W1964875700A5025274207 @default.
• W1964875700 hasAuthorship W1964875700A5041065733 @default.
• W1964875700 hasAuthorship W1964875700A5066013141 @default.
• W1964875700 hasAuthorship W1964875700A5074279833 @default.
• W1964875700 hasConcept C126322002 @default.
• W1964875700 hasConcept C142724271 @default.
• W1964875700 hasConcept C202751555 @default.
• W1964875700 hasConcept C203014093 @default.
• W1964875700 hasConcept C204232928 @default.
• W1964875700 hasConcept C2775862500 @default.
• W1964875700 hasConcept C2776280935 @default.
• W1964875700 hasConcept C2776914184 @default.
• W1964875700 hasConcept C2778260677 @default.
• W1964875700 hasConcept C2778690821 @default.
• W1964875700 hasConcept C2779134260 @default.
• W1964875700 hasConcept C2779244956 @default.
• W1964875700 hasConcept C2779280984 @default.
• W1964875700 hasConcept C2780479503 @default.
• W1964875700 hasConcept C2780942790 @default.
• W1964875700 hasConcept C50442881 @default.
• W1964875700 hasConcept C55493867 @default.
• W1964875700 hasConcept C71924100 @default.
• W1964875700 hasConcept C86803240 @default.
• W1964875700 hasConceptScore W1964875700C126322002 @default.
• W1964875700 hasConceptScore W1964875700C142724271 @default.
• W1964875700 hasConceptScore W1964875700C202751555 @default.
• W1964875700 hasConceptScore W1964875700C203014093 @default.
• W1964875700 hasConceptScore W1964875700C204232928 @default.
• W1964875700 hasConceptScore W1964875700C2775862500 @default.
• W1964875700 hasConceptScore W1964875700C2776280935 @default.
• W1964875700 hasConceptScore W1964875700C2776914184 @default.
• W1964875700 hasConceptScore W1964875700C2778260677 @default.
• W1964875700 hasConceptScore W1964875700C2778690821 @default.
• W1964875700 hasConceptScore W1964875700C2779134260 @default.
• W1964875700 hasConceptScore W1964875700C2779244956 @default.
• W1964875700 hasConceptScore W1964875700C2779280984 @default.
• W1964875700 hasConceptScore W1964875700C2780479503 @default.
• W1964875700 hasConceptScore W1964875700C2780942790 @default.
• W1964875700 hasConceptScore W1964875700C50442881 @default.
• W1964875700 hasConceptScore W1964875700C55493867 @default.
• W1964875700 hasConceptScore W1964875700C71924100 @default.

• next