FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964883357> ?p ?o ?g. }

• W1964883357 endingPage "118" @default.
• W1964883357 startingPage "113" @default.
• W1964883357 abstract "The 21st Century Bioanalytical Laboratory Platforms initiative in the BIOTEC section of the American Association of Pharmaceutical Scientists (AAPS) began with a pre-conference workshop held in Seattle, WA in June of 2009. This workshop brought together members of the pharmaceutical and biotechnology industries, with instrument and reagent manufacturers to discuss the current and potential future state of the bioanalytical laboratories supporting biologics development. At the conclusion of the workshop, four sub-teams were formed to further develop the ideas and concepts raised during the 2-day workshop. The sub-teams are reagents, automation, e-solutions, and platforms. This paper discusses the critical attributes of a research and development ligand binding assay (LBA) platform and the desired characteristics new platforms should strive to offer in the future. This paper is not intended to be a review and comparison of the current platforms on the market, as this has been done and published elsewhere (1–9).The platforms team consists of a balanced cross-section of the industry with representatives from pharmaceutical, biotechnology, contract research organizations, and instrument manufacturers. The Platforms team have collaborated to discuss and arrive at a consensus regarding the most useful characteristics of a bioanalytical platform for biologics. We present here the results of these discussions.A platform is the technology employed in an analytical method to transduce a biochemical event into a measureable output or signal. This signal allows the bioanalytical scientist to accurately and reproducibly make measurements to analyze different aspects of a specific biologic target (therapeutic, biomarker, and anti-drug antibody) such as its pharmacokinetics, immunogenicity, potency, or effect of biomarkers. An instrument is the tool utilized minimally to measure a platform’s output and convert the resultant signal into interpretable information the analytical scientist can use but can incorporate other aspects such as liquid handling. Many platforms employ optical signals including the absorbance of light through a medium (10) or the emission of fluorescence (10) or luminescence (11). A variety of light detectors are used to measure these optical signals including photo diodes, charge-coupled device cameras, and photo-multiplier tubes (Table I). Sections in this paper provide details on the desirable analytical characteristics, multiplexing, platform flexibility and throughput, desirable instrument characteristics, and finally, life cycle management of the ideal LBA platform.Table ICommonly Used PlatformsThe analytical characteristics of today’s ligand binding assays are primarily influenced by three major factors—the quality of the reagents, assay format, and the choice of the analytical platform. This paper describes only those aspects derived from the analytical platform." @default.
• W1964883357 created "2016-06-24" @default.
• W1964883357 creator A5008481962 @default.
• W1964883357 creator A5010675395 @default.
• W1964883357 creator A5018853643 @default.
• W1964883357 creator A5022553469 @default.
• W1964883357 creator A5036616484 @default.
• W1964883357 creator A5039271420 @default.
• W1964883357 creator A5040252260 @default.
• W1964883357 creator A5044314387 @default.
• W1964883357 creator A5062970684 @default.
• W1964883357 creator A5063231071 @default.
• W1964883357 creator A5066733114 @default.
• W1964883357 creator A5075965691 @default.
• W1964883357 creator A5085642611 @default.
• W1964883357 date "2012-01-19" @default.
• W1964883357 modified "2023-09-26" @default.
• W1964883357 title "Ligand Binding Assays in the 21st Century Laboratory: Platforms" @default.
• W1964883357 cites W1936218468 @default.
• W1964883357 cites W1967295501 @default.
• W1964883357 cites W1991458027 @default.
• W1964883357 cites W1997496599 @default.
• W1964883357 cites W2007578147 @default.
• W1964883357 cites W2018041017 @default.
• W1964883357 cites W2025853915 @default.
• W1964883357 cites W2030125105 @default.
• W1964883357 cites W2032353819 @default.
• W1964883357 cites W2046877602 @default.
• W1964883357 cites W2049880765 @default.
• W1964883357 cites W2053315917 @default.
• W1964883357 cites W2062263519 @default.
• W1964883357 cites W2069506532 @default.
• W1964883357 cites W2077531162 @default.
• W1964883357 cites W2087641054 @default.
• W1964883357 cites W2130669407 @default.
• W1964883357 cites W2132071446 @default.
• W1964883357 cites W2132368131 @default.
• W1964883357 cites W2162428378 @default.
• W1964883357 doi "https://doi.org/10.1208/s12248-012-9321-1" @default.
• W1964883357 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3291195" @default.
• W1964883357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22454839" @default.
• W1964883357 hasPublicationYear "2012" @default.
• W1964883357 type Work @default.
• W1964883357 sameAs 1964883357 @default.
• W1964883357 citedByCount "16" @default.
• W1964883357 countsByYear W19648833572012 @default.
• W1964883357 countsByYear W19648833572013 @default.
• W1964883357 countsByYear W19648833572014 @default.
• W1964883357 countsByYear W19648833572015 @default.
• W1964883357 countsByYear W19648833572016 @default.
• W1964883357 countsByYear W19648833572017 @default.
• W1964883357 countsByYear W19648833572019 @default.
• W1964883357 countsByYear W19648833572022 @default.
• W1964883357 crossrefType "journal-article" @default.
• W1964883357 hasAuthorship W1964883357A5008481962 @default.
• W1964883357 hasAuthorship W1964883357A5010675395 @default.
• W1964883357 hasAuthorship W1964883357A5018853643 @default.
• W1964883357 hasAuthorship W1964883357A5022553469 @default.
• W1964883357 hasAuthorship W1964883357A5036616484 @default.
• W1964883357 hasAuthorship W1964883357A5039271420 @default.
• W1964883357 hasAuthorship W1964883357A5040252260 @default.
• W1964883357 hasAuthorship W1964883357A5044314387 @default.
• W1964883357 hasAuthorship W1964883357A5062970684 @default.
• W1964883357 hasAuthorship W1964883357A5063231071 @default.
• W1964883357 hasAuthorship W1964883357A5066733114 @default.
• W1964883357 hasAuthorship W1964883357A5075965691 @default.
• W1964883357 hasAuthorship W1964883357A5085642611 @default.
• W1964883357 hasBestOaLocation W19648833572 @default.
• W1964883357 hasConcept C116569031 @default.
• W1964883357 hasConcept C170493617 @default.
• W1964883357 hasConcept C171250308 @default.
• W1964883357 hasConcept C185592680 @default.
• W1964883357 hasConcept C192562407 @default.
• W1964883357 hasConcept C55493867 @default.
• W1964883357 hasConcept C70721500 @default.
• W1964883357 hasConcept C86803240 @default.
• W1964883357 hasConceptScore W1964883357C116569031 @default.
• W1964883357 hasConceptScore W1964883357C170493617 @default.
• W1964883357 hasConceptScore W1964883357C171250308 @default.
• W1964883357 hasConceptScore W1964883357C185592680 @default.
• W1964883357 hasConceptScore W1964883357C192562407 @default.
• W1964883357 hasConceptScore W1964883357C55493867 @default.
• W1964883357 hasConceptScore W1964883357C70721500 @default.
• W1964883357 hasConceptScore W1964883357C86803240 @default.
• W1964883357 hasIssue "1" @default.
• W1964883357 hasLocation W19648833571 @default.
• W1964883357 hasLocation W19648833572 @default.
• W1964883357 hasLocation W19648833573 @default.
• W1964883357 hasLocation W19648833574 @default.
• W1964883357 hasOpenAccess W1964883357 @default.
• W1964883357 hasPrimaryLocation W19648833571 @default.
• W1964883357 hasRelatedWork W1531601525 @default.
• W1964883357 hasRelatedWork W1980377213 @default.
• W1964883357 hasRelatedWork W1990781990 @default.
• W1964883357 hasRelatedWork W2607424097 @default.
• W1964883357 hasRelatedWork W2739417245 @default.
• W1964883357 hasRelatedWork W2748952813 @default.
• W1964883357 hasRelatedWork W2899084033 @default.

• next