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• W1964895324 abstract "The mature oligodendrocyte, though able to divide under certain circumstances, has been regarded as incapable of changing into a phenotypically plastic cell type. To further explore this question, we developed an in vitro system in which a virtually pure population of early postnatal canine oligodendrocytes were cultured in a serum free, defined medium. We tested the oligodendrocytes' morphological and mitotic responses to concentration of basic Fibroblast Growth Factor (bFGF) ranging from 5 ng to 100 ng/ml. We found that bFGF effected both the morphology and mitotic potential of these cells. In addition, oligodendrocytes exposed to bFGF respond to 10% fetal bovine serum (FBS) by undergoing morphological changes that are quite different than naive oligodendrocytes exposed to 10% FBS, suggesting that bFGF causes some fundamental change in plasticity. © 1995 Wiley-Liss, Inc." @default.
• W1964895324 created "2016-06-24" @default.
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• W1964895324 date "1995-05-01" @default.
• W1964895324 modified "2023-09-23" @default.
• W1964895324 title "Canine oligodendrocytes undergo morphological changes in response to basic fibroblast growth factor (bFGF) in vitro" @default.
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• W1964895324 doi "https://doi.org/10.1002/glia.440140106" @default.
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• W1964895324 hasPublicationYear "1995" @default.
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