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• W1964898159 endingPage "1297" @default.
• W1964898159 startingPage "1287" @default.
• W1964898159 abstract "Introduction: Prophylactic treatment with replacement clotting factor is the recommended regimen for patients with severe hemophilia to prevent bleeding episodes. However, currently available replacement clotting factors are limited by their relatively short half-lives and require intravenous injections up to three times weekly to maintain protective levels, which can impact compliance and, thus, patient outcomes. Areas covered: The potential advantages of long-acting coagulation factors, including reduced injection frequency, increased treatment adherence, and improved clinical outcomes, are discussed. Fragment crystallizable (Fc) fusion technology is introduced and the development of long-acting recombinant factor VIII Fc (rFVIIIFc) and recombinant factor IX Fc (rFIXFc) fusion proteins for the treatment of hemophilia A and B, respectively, are described. Preclinical and clinical studies of rFVIIIFc and rFIXFc showing improved pharmacokinetics over currently available products are reviewed. Expert opinion: Long-acting coagulation factors, including rFVIIIFc and rFIXFc, have the potential to change current paradigms of care for hemophilia A and B, respectively. Less frequent infusions may provide prolonged protection from bleeding and bleed resolution with fewer injections. In addition, long-acting coagulation factors provide an opportunity for improved individualized treatment for hemophilia." @default.
• W1964898159 created "2016-06-24" @default.
• W1964898159 creator A5038597185 @default.
• W1964898159 date "2013-08-10" @default.
• W1964898159 modified "2023-09-24" @default.
• W1964898159 title "Development of long-acting recombinant FVIII and FIX Fc fusion proteins for the management of hemophilia" @default.
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• W1964898159 doi "https://doi.org/10.1517/14712598.2013.819339" @default.
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