Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964908114> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1964908114 abstract "Anthracycline adjuvant therapy has taken a particular role in the treatment of early stage breast cancer with an associated decrease in rates of both relapse and death. Their success however has been limited by their myelosuppression and their well-established risk of cardiac dysfunction. Guidelines have emerged that would limit the maximum lifetime dose of anthracyclines and make a baseline assessment and periodic monitoring of cardiac function part of the routine practice, which could be cumbersome, and may condemn the patient to an unwarranted modification of his/her regimen. Our study aimed at assessing the incidence of abnormal baseline echocardiography in asymptomatic women with breast cancer prior to anthracycline therapy and establishing risk criteria associated with abnormal echocardiograms at baseline. 220 Patients seen at AUBMC (American University of Beirut Medical Center) who had non- metastatic breast cancer, and had an echocardiography performed before starting anthracycline chemotherapy were chosen. Data about demographic characteristics, tumor characteristics, baseline echocardiography results, and change in clinical decision was collected. Patients with suboptimal (less than 50%) ejection fraction (EF) on baseline echocardiography were analyzed for the prevalence of cardiac risk factors. Results were compared to those among the overall study group using Fisher’s Exact test. A p- value of = < 0.05 was used as reference for statistical significance. All 220 of our patients had received a baseline echo prior to initiation of anthracycline therapy. 6.7% of these patients had already some abnormality in wall motion but only 2.7% had a suboptimal ejection fraction. 1.3% had a change in chemotherapy regimen based on ejection fraction. The patients with depressed EF had higher rates of CAD (coronary artery disease), diabetes, hypertension and dyslipidemia than the overall study group but without statistical significance. Our study, as well as the previous contingent studies raise the question about routine echocardiography prior to anthracycline therapy and might eventually lead to a modification of current practice guidelines." @default.
- W1964908114 created "2016-06-24" @default.
- W1964908114 creator A5003341212 @default.
- W1964908114 creator A5019505411 @default.
- W1964908114 creator A5041917404 @default.
- W1964908114 creator A5046337431 @default.
- W1964908114 creator A5074969801 @default.
- W1964908114 creator A5090339977 @default.
- W1964908114 date "2015-01-21" @default.
- W1964908114 modified "2023-09-25" @default.
- W1964908114 title "Role of baseline echocardiography prior to initiation of anthracycline-based chemotherapy in breast cancer patients" @default.
- W1964908114 cites W166128565 @default.
- W1964908114 cites W201396144 @default.
- W1964908114 cites W2048550637 @default.
- W1964908114 cites W2089448457 @default.
- W1964908114 cites W2112351355 @default.
- W1964908114 cites W2136867800 @default.
- W1964908114 cites W2142660045 @default.
- W1964908114 cites W2263604613 @default.
- W1964908114 cites W2318883379 @default.
- W1964908114 cites W2411627456 @default.
- W1964908114 doi "https://doi.org/10.1186/s12885-014-1004-0" @default.
- W1964908114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4311428" @default.
- W1964908114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25605569" @default.
- W1964908114 hasPublicationYear "2015" @default.
- W1964908114 type Work @default.
- W1964908114 sameAs 1964908114 @default.
- W1964908114 citedByCount "9" @default.
- W1964908114 countsByYear W19649081142017 @default.
- W1964908114 countsByYear W19649081142018 @default.
- W1964908114 countsByYear W19649081142019 @default.
- W1964908114 countsByYear W19649081142021 @default.
- W1964908114 countsByYear W19649081142023 @default.
- W1964908114 crossrefType "journal-article" @default.
- W1964908114 hasAuthorship W1964908114A5003341212 @default.
- W1964908114 hasAuthorship W1964908114A5019505411 @default.
- W1964908114 hasAuthorship W1964908114A5041917404 @default.
- W1964908114 hasAuthorship W1964908114A5046337431 @default.
- W1964908114 hasAuthorship W1964908114A5074969801 @default.
- W1964908114 hasAuthorship W1964908114A5090339977 @default.
- W1964908114 hasBestOaLocation W19649081141 @default.
- W1964908114 hasConcept C121608353 @default.
- W1964908114 hasConcept C126322002 @default.
- W1964908114 hasConcept C143998085 @default.
- W1964908114 hasConcept C164705383 @default.
- W1964908114 hasConcept C2776802502 @default.
- W1964908114 hasConcept C2777910003 @default.
- W1964908114 hasConcept C2778198053 @default.
- W1964908114 hasConcept C2780140570 @default.
- W1964908114 hasConcept C530470458 @default.
- W1964908114 hasConcept C71924100 @default.
- W1964908114 hasConcept C78085059 @default.
- W1964908114 hasConceptScore W1964908114C121608353 @default.
- W1964908114 hasConceptScore W1964908114C126322002 @default.
- W1964908114 hasConceptScore W1964908114C143998085 @default.
- W1964908114 hasConceptScore W1964908114C164705383 @default.
- W1964908114 hasConceptScore W1964908114C2776802502 @default.
- W1964908114 hasConceptScore W1964908114C2777910003 @default.
- W1964908114 hasConceptScore W1964908114C2778198053 @default.
- W1964908114 hasConceptScore W1964908114C2780140570 @default.
- W1964908114 hasConceptScore W1964908114C530470458 @default.
- W1964908114 hasConceptScore W1964908114C71924100 @default.
- W1964908114 hasConceptScore W1964908114C78085059 @default.
- W1964908114 hasIssue "1" @default.
- W1964908114 hasLocation W19649081141 @default.
- W1964908114 hasLocation W19649081142 @default.
- W1964908114 hasLocation W19649081143 @default.
- W1964908114 hasLocation W19649081144 @default.
- W1964908114 hasOpenAccess W1964908114 @default.
- W1964908114 hasPrimaryLocation W19649081141 @default.
- W1964908114 hasRelatedWork W1902373755 @default.
- W1964908114 hasRelatedWork W1968212672 @default.
- W1964908114 hasRelatedWork W2107831372 @default.
- W1964908114 hasRelatedWork W2123174954 @default.
- W1964908114 hasRelatedWork W2288724904 @default.
- W1964908114 hasRelatedWork W2590604187 @default.
- W1964908114 hasRelatedWork W2591616149 @default.
- W1964908114 hasRelatedWork W2913374104 @default.
- W1964908114 hasRelatedWork W3146895482 @default.
- W1964908114 hasRelatedWork W3186932410 @default.
- W1964908114 hasVolume "15" @default.
- W1964908114 isParatext "false" @default.
- W1964908114 isRetracted "false" @default.
- W1964908114 magId "1964908114" @default.
- W1964908114 workType "article" @default.