FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964908330> ?p ?o ?g. }

• W1964908330 endingPage "113" @default.
• W1964908330 startingPage "78" @default.
• W1964908330 abstract "PTH is a major systemic regulator of the concentrations of calcium, phosphate, and active vitamin D metabolites in blood and of cellular activity in bone. Intermittently administered PTH and amino-terminal PTH peptide fragments or analogs also augment bone mass and currently are being introduced into clinical practice as therapies for osteoporosis. The amino-terminal region of PTH is known to be both necessary and sufficient for full activity at PTH/PTHrP receptors (PTH1Rs), which mediate the classical biological actions of the hormone. It is well known that multiple carboxyl-terminal fragments of PTH are present in blood, where they comprise the major form(s) of circulating hormone, but these fragments have long been regarded as inert by-products of PTH metabolism because they neither bind to nor activate PTH1Rs. New in vitro and in vivo evidence, together with older observations extending over the past 20 yr, now points strongly to the existence of novel large carboxyl-terminal PTH fragments in blood and to receptors for these fragments that appear to mediate unique biological actions in bone. This review traces the development of this field in the context of the evolution of our understanding of the classical receptor for amino-terminal PTH and the now convincing evidence for these receptors for carboxyl-terminal PTH. The review summarizes current knowledge of the structure, secretion, and metabolism of PTH and its circulating fragments, details available information concerning the pharmacology and actions of carboxyl-terminal PTH receptors, and frames their likely biological and clinical significance. It seems likely that physiological parathyroid regulation of calcium and bone metabolism may involve receptors for circulating carboxy-terminal PTH ligands as well as the action of amino-terminal determinants within the PTH molecule on the classical PTH1R." @default.
• W1964908330 created "2016-06-24" @default.
• W1964908330 creator A5004587580 @default.
• W1964908330 creator A5004762242 @default.
• W1964908330 creator A5019506956 @default.
• W1964908330 creator A5043288674 @default.
• W1964908330 date "2004-11-16" @default.
• W1964908330 modified "2023-10-10" @default.
• W1964908330 title "Parathyroid Hormone Secretion and Action: Evidence for Discrete Receptors for the Carboxyl-Terminal Region and Related Biological Actions of Carboxyl-Terminal Ligands" @default.
• W1964908330 cites W120177119 @default.
• W1964908330 cites W133124721 @default.
• W1964908330 cites W1489035442 @default.
• W1964908330 cites W1491890613 @default.
• W1964908330 cites W1495121385 @default.
• W1964908330 cites W1495437191 @default.
• W1964908330 cites W1498411345 @default.
• W1964908330 cites W1499143977 @default.
• W1964908330 cites W1499942184 @default.
• W1964908330 cites W1502554723 @default.
• W1964908330 cites W1508804340 @default.
• W1964908330 cites W1512706043 @default.
• W1964908330 cites W1530894594 @default.
• W1964908330 cites W1536310816 @default.
• W1964908330 cites W1537520293 @default.
• W1964908330 cites W1537691466 @default.
• W1964908330 cites W1561419139 @default.
• W1964908330 cites W1561488685 @default.
• W1964908330 cites W1562969614 @default.
• W1964908330 cites W1565298428 @default.
• W1964908330 cites W1577776424 @default.
• W1964908330 cites W1581434205 @default.
• W1964908330 cites W1584053150 @default.
• W1964908330 cites W1589893072 @default.
• W1964908330 cites W1592400272 @default.
• W1964908330 cites W1593282819 @default.
• W1964908330 cites W1598835488 @default.
• W1964908330 cites W1600683109 @default.
• W1964908330 cites W1607276167 @default.
• W1964908330 cites W1607921586 @default.
• W1964908330 cites W1608208747 @default.
• W1964908330 cites W1608683075 @default.
• W1964908330 cites W1900065912 @default.
• W1964908330 cites W1938339522 @default.
• W1964908330 cites W1964086646 @default.
• W1964908330 cites W1964324757 @default.
• W1964908330 cites W1965048273 @default.
• W1964908330 cites W1965121803 @default.
• W1964908330 cites W1965937833 @default.
• W1964908330 cites W1965942863 @default.
• W1964908330 cites W1965963242 @default.
• W1964908330 cites W1966591888 @default.
• W1964908330 cites W1967194189 @default.
• W1964908330 cites W1967301186 @default.
• W1964908330 cites W1968093456 @default.
• W1964908330 cites W1968322079 @default.
• W1964908330 cites W1968710675 @default.
• W1964908330 cites W1968950287 @default.
• W1964908330 cites W1969080702 @default.
• W1964908330 cites W1969568665 @default.
• W1964908330 cites W1970121423 @default.
• W1964908330 cites W1970131674 @default.
• W1964908330 cites W1970150252 @default.
• W1964908330 cites W1971753539 @default.
• W1964908330 cites W1972285228 @default.
• W1964908330 cites W1972745909 @default.
• W1964908330 cites W1972861607 @default.
• W1964908330 cites W1973421786 @default.
• W1964908330 cites W1974953 @default.
• W1964908330 cites W1975374649 @default.
• W1964908330 cites W1976265107 @default.
• W1964908330 cites W1976319973 @default.
• W1964908330 cites W1977013832 @default.
• W1964908330 cites W1977779793 @default.
• W1964908330 cites W1977811131 @default.
• W1964908330 cites W1978821848 @default.
• W1964908330 cites W1979190014 @default.
• W1964908330 cites W1979950308 @default.
• W1964908330 cites W1979980462 @default.
• W1964908330 cites W1980875495 @default.
• W1964908330 cites W1981197886 @default.
• W1964908330 cites W1981423987 @default.
• W1964908330 cites W1982164154 @default.
• W1964908330 cites W1982433689 @default.
• W1964908330 cites W1984706987 @default.
• W1964908330 cites W1984822376 @default.
• W1964908330 cites W1984986047 @default.
• W1964908330 cites W1987227128 @default.
• W1964908330 cites W1987444061 @default.
• W1964908330 cites W1987725877 @default.
• W1964908330 cites W1988498648 @default.
• W1964908330 cites W1988802314 @default.
• W1964908330 cites W1988873034 @default.
• W1964908330 cites W1988926732 @default.
• W1964908330 cites W1989106910 @default.
• W1964908330 cites W1989287013 @default.
• W1964908330 cites W1989456694 @default.
• W1964908330 cites W1989475637 @default.
• W1964908330 cites W1989809282 @default.

• next