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- W1964912566 abstract "cAMP-dependent protein kinase (PKA) and phospholipid-dependent protein kinase (PKC) play a role in nerve growth factor (NGF)-mediated differentiation. In PC12 cells, NGF causes neurite outgrowth and increases the number of voltage-gated Na+ channels. Neurite outgrowth involves in part activation of PKC. How NGF regulates Na+ channel number is unknown. Using patch-clamp techniques, we find that agents activating PKC, including phorbol esters and a ras oncogene product (p21) that induces neurites, caused little increase in channel number. In contrast, agents increasing intracellular cAMP were as effective as NGF. A specific protein inhibitor of the PKA catalytic subunit blocked increases by NGF or cAMP. Thus, NGF increases Na+ channel number in PC12 cells in part by activating PKA but apparently not PKC." @default.
- W1964912566 created "2016-06-24" @default.
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- W1964912566 date "1990-03-01" @default.
- W1964912566 modified "2023-09-23" @default.
- W1964912566 title "Nerve growth factor acts through cAMP-dependent protein kinase to increase the number of sodium channels in PC12 cells" @default.
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- W1964912566 doi "https://doi.org/10.1016/0896-6273(90)90048-k" @default.
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