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• W1964927820 abstract "Abstract Airway inflammation may cause alteration of airway responses in chronic airway diseases, such as bronchial asthma. The objective of this study was to examine whether interleukin-18 (IL-18), one of the pro-inflammatory cytokines, has a direct effect on airway functions. The effects of IL-18 on carbachol, KC1 and isoproterenol (ISO) responses of isolated guinea-pig tracheal strips were examined by measuring isometric tension in tissue bath. Responses of tracheal strips with or without epithelium to each agonist were compared before and after incubation with IL-18 (25 ng or 250 ng/mL). Both 1 h and 5 h incubation of the strips with 250 ng/mL IL-18 significantly decreased the sensitivity not only to KC1 (P < 0.05; P < 0.01, respectively), but also to ISO (both P < 0.05) without affecting maximum contraction or relaxation. Response to carbachol was not affected by IL-18. Epithelial denudation abolished the effects of IL-18 on KC1 and ISO responses. Indomethacin (2 9mol/L) reversed the effects of IL-18 both on KC1 and on ISO. These results suggest that IL-1ß decreases the sensitivity of airway strips to KC1 and ISO, possibly by stimulating prostaglandin production from the airway epithelium." @default.
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• W1964927820 date "1996-03-01" @default.
• W1964927820 modified "2023-09-23" @default.
• W1964927820 title "Interleukin-1ß decreases sensitivity of guinea-pig airway to potassium chloride and isoproterenol by an epithelium-dependent mechanism" @default.
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• W1964927820 doi "https://doi.org/10.1111/j.1440-1843.1996.tb00012.x" @default.
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