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- W1964943223 abstract "The guanylyl cyclase C protein, expressed primarily in the intestine, is the receptor for the heat-stable enterotoxin of Escherichia coli. We have isolated and sequenced the promoter region and the first exon of human guanylyl cyclase C and determined the major site of transcription initiation. Transfection of a -1973/+124 promoter/luciferase gene fusion construct in the Caco-2 intestinal cell line resulted in a high level of expression; results with deletion constructs indicate the presence of multiple positive-acting sequence elements. These promoter elements were not active upon transfection into NIH/3T3 and LLC-PK1 cell lines which do not express GC-C." @default.
- W1964943223 created "2016-06-24" @default.
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- W1964943223 date "1996-02-01" @default.
- W1964943223 modified "2023-10-14" @default.
- W1964943223 title "Cell line-specific transcriptional activation of the promoter of the human guanylyl cyclase C/heat-stable enterotoxin receptor gene" @default.
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- W1964943223 doi "https://doi.org/10.1016/0167-4781(95)00190-5" @default.
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