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• W1964977461 abstract "Infantile hemangioma (IH) is a rapidly growing vascular tumor affecting newborns. It is composed of immature endothelial cells and pericytes that proliferate into a disorganized mass of blood vessels. We isolated pericytes from IH (Hem-pericytes) to test our hypothesis that Hem-pericytes are unable to stabilize blood vessels.We injected pericytes in vivo, in combination with endothelial cells, and found that Hem-pericytes formed more microvessels compared with control retinal pericytes. We, thereby, analyzed proangiogenic properties of the Hem-pericytes. They grew fast in vitro, and were unable to stabilize endothelial cell growth and migration, and expressed high levels of vascular endothelial growth factor-A compared with retinal pericytes. Hem-pericytes from proliferating phase IH showed lower contractility in vitro, compared with Hem-pericytes from the involuting phase and retinal pericytes. Consistent with a diminished ability to stabilize endothelium, angiopoietin 1 was reduced in Hem-pericytes compared with retinal pericytes. Normal retinal pericytes in which angiopoietin 1 was silenced produced conditioned medium that stimulated endothelial cell proliferation and migration.We report the first successful isolation of patient-derived pericytes from IH tissue. Hem-pericytes exhibited proangiogenic properties and low levels of angiopoietin 1, consistent with a diminished ability to stabilize blood vessels in IH." @default.
• W1964977461 created "2016-06-24" @default.
• W1964977461 creator A5017036595 @default.
• W1964977461 creator A5066532151 @default.
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• W1964977461 date "2013-03-01" @default.
• W1964977461 modified "2023-10-16" @default.
• W1964977461 title "Pericytes From Infantile Hemangioma Display Proangiogenic Properties and Dysregulated Angiopoietin-1" @default.
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• W1964977461 doi "https://doi.org/10.1161/atvbaha.112.300929" @default.
• W1964977461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3573237" @default.
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