FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964978438> ?p ?o ?g. }

• W1964978438 endingPage "1120" @default.
• W1964978438 startingPage "1107" @default.
• W1964978438 abstract "The Saccharomyces cerevisiae SGS1 gene is a member of the RecQ family of ATP-dependent DNA helicases, which includes the human WRN, BLM and RECQ4 genes. Mutations in the WRN gene cause the human premature ageing disorder, Werner's syndrome. Deletion of the SGS1 gene also causes premature ageing in yeast, suggesting that the molecular mechanisms of cellular ageing may be evolutionarily conserved. To investigate the role of the RecQ helicase domain in ageing, a point mutation (SGS1 K(706)-->A) known to eliminate the DNA helicase activity of Sgs1p was constructed. This mutant allele failed to rescue the premature ageing of the sgs1Delta strain, demonstrating that Sgs1p DNA helicase activity is required for a normal lifespan. In contrast, the SGS1 K(706)-->A allele was sufficient to rescue the hypersensitivity of the sgs1Delta strain to topoisomerase inhibitors, but not other genotoxic agents. These findings support the idea that Sgs1p fulfils multiple cellular functions, and that DNA helicase activity is dispensable for some of these (e.g. functional interaction with topoisomerases), but essential for others (e.g. longevity)." @default.
• W1964978438 created "2016-06-24" @default.
• W1964978438 creator A5027199540 @default.
• W1964978438 creator A5060258496 @default.
• W1964978438 date "2001-08-01" @default.
• W1964978438 modified "2023-09-24" @default.
• W1964978438 title "The DNA helicase activity of yeast Sgs1p is essential for normal lifespan but not for resistance to topoisomerase inhibitors" @default.
• W1964978438 cites W122675378 @default.
• W1964978438 cites W1523619671 @default.
• W1964978438 cites W1926322311 @default.
• W1964978438 cites W1935801587 @default.
• W1964978438 cites W1963563101 @default.
• W1964978438 cites W1963578989 @default.
• W1964978438 cites W1966347623 @default.
• W1964978438 cites W1967390330 @default.
• W1964978438 cites W1969336380 @default.
• W1964978438 cites W1970898019 @default.
• W1964978438 cites W1971438029 @default.
• W1964978438 cites W1975817860 @default.
• W1964978438 cites W1983650797 @default.
• W1964978438 cites W1989971670 @default.
• W1964978438 cites W1995702418 @default.
• W1964978438 cites W1996542243 @default.
• W1964978438 cites W2001193188 @default.
• W1964978438 cites W2025255779 @default.
• W1964978438 cites W2026766143 @default.
• W1964978438 cites W2027923136 @default.
• W1964978438 cites W2030792701 @default.
• W1964978438 cites W2039996950 @default.
• W1964978438 cites W2049160479 @default.
• W1964978438 cites W2050717008 @default.
• W1964978438 cites W2064310741 @default.
• W1964978438 cites W2073483575 @default.
• W1964978438 cites W2078030859 @default.
• W1964978438 cites W2082557856 @default.
• W1964978438 cites W2084712319 @default.
• W1964978438 cites W2085081661 @default.
• W1964978438 cites W2102345056 @default.
• W1964978438 cites W2105778779 @default.
• W1964978438 cites W2109714973 @default.
• W1964978438 cites W2129225238 @default.
• W1964978438 cites W2134312430 @default.
• W1964978438 cites W2162358123 @default.
• W1964978438 doi "https://doi.org/10.1016/s0047-6374(01)00253-6" @default.
• W1964978438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11389927" @default.
• W1964978438 hasPublicationYear "2001" @default.
• W1964978438 type Work @default.
• W1964978438 sameAs 1964978438 @default.
• W1964978438 citedByCount "18" @default.
• W1964978438 countsByYear W19649784382012 @default.
• W1964978438 countsByYear W19649784382020 @default.
• W1964978438 crossrefType "journal-article" @default.
• W1964978438 hasAuthorship W1964978438A5027199540 @default.
• W1964978438 hasAuthorship W1964978438A5060258496 @default.
• W1964978438 hasConcept C104317684 @default.
• W1964978438 hasConcept C134935766 @default.
• W1964978438 hasConcept C143065580 @default.
• W1964978438 hasConcept C147897179 @default.
• W1964978438 hasConcept C153911025 @default.
• W1964978438 hasConcept C161223559 @default.
• W1964978438 hasConcept C176944494 @default.
• W1964978438 hasConcept C2777576037 @default.
• W1964978438 hasConcept C2778090637 @default.
• W1964978438 hasConcept C2780751114 @default.
• W1964978438 hasConcept C2909947164 @default.
• W1964978438 hasConcept C501734568 @default.
• W1964978438 hasConcept C54355233 @default.
• W1964978438 hasConcept C552990157 @default.
• W1964978438 hasConcept C67705224 @default.
• W1964978438 hasConcept C86803240 @default.
• W1964978438 hasConceptScore W1964978438C104317684 @default.
• W1964978438 hasConceptScore W1964978438C134935766 @default.
• W1964978438 hasConceptScore W1964978438C143065580 @default.
• W1964978438 hasConceptScore W1964978438C147897179 @default.
• W1964978438 hasConceptScore W1964978438C153911025 @default.
• W1964978438 hasConceptScore W1964978438C161223559 @default.
• W1964978438 hasConceptScore W1964978438C176944494 @default.
• W1964978438 hasConceptScore W1964978438C2777576037 @default.
• W1964978438 hasConceptScore W1964978438C2778090637 @default.
• W1964978438 hasConceptScore W1964978438C2780751114 @default.
• W1964978438 hasConceptScore W1964978438C2909947164 @default.
• W1964978438 hasConceptScore W1964978438C501734568 @default.
• W1964978438 hasConceptScore W1964978438C54355233 @default.
• W1964978438 hasConceptScore W1964978438C552990157 @default.
• W1964978438 hasConceptScore W1964978438C67705224 @default.
• W1964978438 hasConceptScore W1964978438C86803240 @default.
• W1964978438 hasIssue "11" @default.
• W1964978438 hasLocation W19649784381 @default.
• W1964978438 hasLocation W19649784382 @default.
• W1964978438 hasOpenAccess W1964978438 @default.
• W1964978438 hasPrimaryLocation W19649784381 @default.
• W1964978438 hasRelatedWork W1859750913 @default.
• W1964978438 hasRelatedWork W1964978438 @default.
• W1964978438 hasRelatedWork W2024302525 @default.
• W1964978438 hasRelatedWork W2034837321 @default.
• W1964978438 hasRelatedWork W2048650794 @default.
• W1964978438 hasRelatedWork W2088443859 @default.
• W1964978438 hasRelatedWork W2129363800 @default.

• next