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• W1965005369 abstract "Objective: Our purpose was to examine whether the type IV collagenases (metalloproteinase [MMP]-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) are regulated by a prostaglandin E2 (PGE2)-cyclic adenosine monophosphate (cAMP) mechanism in nonpregnant virgin, preterm and term pregnant and postpartum rats. Study Design: Sprague-Dawley rats were infused with either saline solution or PGE2 over 24 hours or were noninfused. Plasma and tissue were analyzed for cAMP, MMP-2 and MMP-9, and TIMP-1 and TIMP-2. Results: PGE2 evoked elevations in plasma and tissue levels of cAMP and MMP-2 in the preterm and term pregnant rats. MMP-9 levels were elevated in the preterm plasma and uterus, whereas in the term pregnant and postpartum rats, MMP-9 levels were increased in the cervix. Conclusions: MMP levels in the pregnant and postpartum rat uterus and cervix are regulated in part by a PGE2-cAMP mechanism. Specifically, MMP-9 may be involved in preterm labor, cervical maturity, and involution of the postpartum uterus. (Am J Obstet Gynecol 2002;187:202-8.)" @default.
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• W1965005369 date "2002-07-01" @default.
• W1965005369 modified "2023-10-11" @default.
• W1965005369 title "Regulation of matrix metalloproteinases (type IV collagenases) and their inhibitors in the virgin, timed pregnant, and postpartum rat uterus and cervix by prostaglandin E2-cyclic adenosine monophosphate" @default.
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• W1965005369 doi "https://doi.org/10.1067/mob.2002.123543" @default.
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