FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965012883> ?p ?o ?g. }

• W1965012883 endingPage "1460" @default.
• W1965012883 startingPage "1455" @default.
• W1965012883 abstract "Human osteoblasts sense mechanical stimulation and synthesise type I collagen in periprosthetic osseointegration following total hip arthroplasty. However, the regulation of type I collagen synthesis by periprosthetic strain is unclear because the cellular-level strain magnitude remains unknown to date. Fortunately, the tissue-level strain in implanted femurs is measurable. According to the mechanism of strain amplification, the tissue-level strain was amplified 20 times to stretch human osteoblasts in this study. Elongation of 0.8–3.2% enhanced the mRNA level of type I collagen, whereas the release of procollagen type I C propeptide only increased at 2.4% and 3.2% elongation. Type I collagen expression increased with the activation of ERK1/2 phosphorylation in a strain-magnitude-dependent manner, whereas JNK and P38 were unaffected. The responses were completely inhibited by blocking the ERK1/2 pathway with U0126. The results indicate that type I collagen synthesis in human osteoblasts depends on the level of periprosthetic strain and ERK1/2 activation." @default.
• W1965012883 created "2016-06-24" @default.
• W1965012883 creator A5007709310 @default.
• W1965012883 creator A5042956973 @default.
• W1965012883 creator A5053700629 @default.
• W1965012883 creator A5063969408 @default.
• W1965012883 creator A5084893043 @default.
• W1965012883 date "2009-02-12" @default.
• W1965012883 modified "2023-09-25" @default.
• W1965012883 title "Periprosthetic strain magnitude-dependent upregulation of type I collagen synthesis in human osteoblasts through an ERK1/2 pathway" @default.
• W1965012883 cites W1967333075 @default.
• W1965012883 cites W1968967182 @default.
• W1965012883 cites W1975002113 @default.
• W1965012883 cites W1983751437 @default.
• W1965012883 cites W1990886926 @default.
• W1965012883 cites W2007225045 @default.
• W1965012883 cites W2015993883 @default.
• W1965012883 cites W2021159296 @default.
• W1965012883 cites W2023201005 @default.
• W1965012883 cites W2032474365 @default.
• W1965012883 cites W2034562580 @default.
• W1965012883 cites W2035698223 @default.
• W1965012883 cites W2044864383 @default.
• W1965012883 cites W2044872763 @default.
• W1965012883 cites W2054361639 @default.
• W1965012883 cites W2067593186 @default.
• W1965012883 cites W2076372662 @default.
• W1965012883 cites W2084909069 @default.
• W1965012883 cites W2085684906 @default.
• W1965012883 cites W2089194398 @default.
• W1965012883 cites W2091815327 @default.
• W1965012883 cites W2095255069 @default.
• W1965012883 cites W2097393454 @default.
• W1965012883 cites W2109884199 @default.
• W1965012883 cites W2123515535 @default.
• W1965012883 cites W2136887516 @default.
• W1965012883 cites W2142167933 @default.
• W1965012883 cites W2146235933 @default.
• W1965012883 cites W2152850515 @default.
• W1965012883 cites W2165668635 @default.
• W1965012883 cites W2318366640 @default.
• W1965012883 doi "https://doi.org/10.1007/s00264-009-0735-z" @default.
• W1965012883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2899140" @default.
• W1965012883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19214505" @default.
• W1965012883 hasPublicationYear "2009" @default.
• W1965012883 type Work @default.
• W1965012883 sameAs 1965012883 @default.
• W1965012883 citedByCount "6" @default.
• W1965012883 countsByYear W19650128832012 @default.
• W1965012883 crossrefType "journal-article" @default.
• W1965012883 hasAuthorship W1965012883A5007709310 @default.
• W1965012883 hasAuthorship W1965012883A5042956973 @default.
• W1965012883 hasAuthorship W1965012883A5053700629 @default.
• W1965012883 hasAuthorship W1965012883A5063969408 @default.
• W1965012883 hasAuthorship W1965012883A5084893043 @default.
• W1965012883 hasBestOaLocation W19650128832 @default.
• W1965012883 hasConcept C104317684 @default.
• W1965012883 hasConcept C105702510 @default.
• W1965012883 hasConcept C112950240 @default.
• W1965012883 hasConcept C11960822 @default.
• W1965012883 hasConcept C12554922 @default.
• W1965012883 hasConcept C126322002 @default.
• W1965012883 hasConcept C127561419 @default.
• W1965012883 hasConcept C141071460 @default.
• W1965012883 hasConcept C153911025 @default.
• W1965012883 hasConcept C185592680 @default.
• W1965012883 hasConcept C191897082 @default.
• W1965012883 hasConcept C192562407 @default.
• W1965012883 hasConcept C24998067 @default.
• W1965012883 hasConcept C2778022156 @default.
• W1965012883 hasConcept C2778120723 @default.
• W1965012883 hasConcept C2778336525 @default.
• W1965012883 hasConcept C2780644872 @default.
• W1965012883 hasConcept C33947775 @default.
• W1965012883 hasConcept C55493867 @default.
• W1965012883 hasConcept C64348721 @default.
• W1965012883 hasConcept C71924100 @default.
• W1965012883 hasConcept C86803240 @default.
• W1965012883 hasConcept C95444343 @default.
• W1965012883 hasConceptScore W1965012883C104317684 @default.
• W1965012883 hasConceptScore W1965012883C105702510 @default.
• W1965012883 hasConceptScore W1965012883C112950240 @default.
• W1965012883 hasConceptScore W1965012883C11960822 @default.
• W1965012883 hasConceptScore W1965012883C12554922 @default.
• W1965012883 hasConceptScore W1965012883C126322002 @default.
• W1965012883 hasConceptScore W1965012883C127561419 @default.
• W1965012883 hasConceptScore W1965012883C141071460 @default.
• W1965012883 hasConceptScore W1965012883C153911025 @default.
• W1965012883 hasConceptScore W1965012883C185592680 @default.
• W1965012883 hasConceptScore W1965012883C191897082 @default.
• W1965012883 hasConceptScore W1965012883C192562407 @default.
• W1965012883 hasConceptScore W1965012883C24998067 @default.
• W1965012883 hasConceptScore W1965012883C2778022156 @default.
• W1965012883 hasConceptScore W1965012883C2778120723 @default.
• W1965012883 hasConceptScore W1965012883C2778336525 @default.
• W1965012883 hasConceptScore W1965012883C2780644872 @default.
• W1965012883 hasConceptScore W1965012883C33947775 @default.
• W1965012883 hasConceptScore W1965012883C55493867 @default.

• next