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- W1965014516 abstract "Chemoprevention is the long-term use of different chemical agents, both synthetic and natural, to prevent or delay the onset of disease. Since colorectal cancer has a significant environmental component, it is an ideal disease in which to evaluate the potential benefits of chemopreventive agents. The polyamines, spermine, spermidine and putrescine have been involved in almost all the steps of colorectal tumorigenesis. Consequently, polyamine biosynthesis and catabolism can be considered as promising targets for cancer chemoprevention. A variety of drug formulations have been tested for their efficacy in affecting polyamines in a strategy of colorectal cancer prevention. Different molecules, such as biosynthesis inhibitors and catabolism inducers, have been proposed alone or in combination with other drugs proved to diminish the colorectal cancer risk. Interestingly, also diet can play a role in cancer prevention by affecting polyamines. Several dietary components, such as probiotics or flavonoids, have been shown to affect the polyamine metabolic pathway in colorectal neoplastic tissue. On the other hand, the polyamines ingested with diet might contrast the above cited effects shown by both drugs and nutritional factors. It is, therefore, fundamental to acquire more data also on these aspects in view of an innovative approach to colorectal oncology. This review summarizes data on the role of polyamine metabolism in neoplastic transformation of colorectal mucosa and as possible target for colorectal cancer chemoprevention. Attention will be focused on the influence of drugs and nutritional factors on polyamine metabolism, as well as the role played by dietary polyamines." @default.
- W1965014516 created "2016-06-24" @default.
- W1965014516 creator A5045868611 @default.
- W1965014516 creator A5070469704 @default.
- W1965014516 creator A5076252926 @default.
- W1965014516 date "2014-08-14" @default.
- W1965014516 modified "2023-10-18" @default.
- W1965014516 title "Pharmacological and dietary agents for colorectal cancer chemoprevention: Effects on polyamine metabolism (Review)" @default.
- W1965014516 cites W1512389276 @default.
- W1965014516 cites W1547594908 @default.
- W1965014516 cites W1592725541 @default.
- W1965014516 cites W1675250359 @default.
- W1965014516 cites W172337120 @default.
- W1965014516 cites W1945492943 @default.
- W1965014516 cites W1964792840 @default.
- W1965014516 cites W1965523204 @default.
- W1965014516 cites W1971124471 @default.
- W1965014516 cites W1974537258 @default.
- W1965014516 cites W1975541489 @default.
- W1965014516 cites W1978631464 @default.
- W1965014516 cites W1983107157 @default.
- W1965014516 cites W1983176420 @default.
- W1965014516 cites W1985085751 @default.
- W1965014516 cites W1987352740 @default.
- W1965014516 cites W1989939369 @default.
- W1965014516 cites W1991407392 @default.
- W1965014516 cites W1993058852 @default.
- W1965014516 cites W1994017345 @default.
- W1965014516 cites W1995665014 @default.
- W1965014516 cites W1998210391 @default.
- W1965014516 cites W2002801265 @default.
- W1965014516 cites W2006685391 @default.
- W1965014516 cites W2007449477 @default.
- W1965014516 cites W2010940834 @default.
- W1965014516 cites W2011582536 @default.
- W1965014516 cites W2014782775 @default.
- W1965014516 cites W2014896667 @default.
- W1965014516 cites W2015139247 @default.
- W1965014516 cites W2015758149 @default.
- W1965014516 cites W2016536572 @default.
- W1965014516 cites W2016715895 @default.
- W1965014516 cites W2020098066 @default.
- W1965014516 cites W2021329013 @default.
- W1965014516 cites W2025808730 @default.
- W1965014516 cites W2025994995 @default.
- W1965014516 cites W2027911316 @default.
- W1965014516 cites W2028766649 @default.
- W1965014516 cites W2028953339 @default.
- W1965014516 cites W2029569943 @default.
- W1965014516 cites W2031267819 @default.
- W1965014516 cites W2032438214 @default.
- W1965014516 cites W2042389058 @default.
- W1965014516 cites W2045175501 @default.
- W1965014516 cites W2045481010 @default.
- W1965014516 cites W2045731346 @default.
- W1965014516 cites W2051124848 @default.
- W1965014516 cites W2051706437 @default.
- W1965014516 cites W2053712835 @default.
- W1965014516 cites W2055652088 @default.
- W1965014516 cites W2057083693 @default.
- W1965014516 cites W2058194275 @default.
- W1965014516 cites W2059586689 @default.
- W1965014516 cites W2066111639 @default.
- W1965014516 cites W2066439912 @default.
- W1965014516 cites W2072227462 @default.
- W1965014516 cites W2072554858 @default.
- W1965014516 cites W2077385255 @default.
- W1965014516 cites W2077598197 @default.
- W1965014516 cites W2077998713 @default.
- W1965014516 cites W2080012770 @default.
- W1965014516 cites W2080705528 @default.
- W1965014516 cites W2086170055 @default.
- W1965014516 cites W2086760913 @default.
- W1965014516 cites W2087913037 @default.
- W1965014516 cites W2091007380 @default.
- W1965014516 cites W2094932797 @default.
- W1965014516 cites W2097235831 @default.
- W1965014516 cites W2098797721 @default.
- W1965014516 cites W2099108518 @default.
- W1965014516 cites W2103495222 @default.
- W1965014516 cites W2103964549 @default.
- W1965014516 cites W2105216380 @default.
- W1965014516 cites W2109763952 @default.
- W1965014516 cites W2109824142 @default.
- W1965014516 cites W2111337712 @default.
- W1965014516 cites W2113834939 @default.
- W1965014516 cites W2118913969 @default.
- W1965014516 cites W2120240705 @default.
- W1965014516 cites W2121463566 @default.
- W1965014516 cites W2124185542 @default.
- W1965014516 cites W2124199744 @default.
- W1965014516 cites W2125891516 @default.
- W1965014516 cites W2131840121 @default.
- W1965014516 cites W2137001235 @default.
- W1965014516 cites W2137520566 @default.
- W1965014516 cites W2141603687 @default.
- W1965014516 cites W2142851289 @default.
- W1965014516 cites W2143095815 @default.