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- W1965020866 abstract "Systemic delivery of bone marrow–derived mesenchymal stem cells (MSCs) is a noninvasive approach for myocardial repair. We aimed to test this strategy in a pig model of myocardial infarction. Pigs (n = 8) received autologous MSCs (1 x 106/kg body weight) labeled with fluorescent dye 48 h post proximal left anterior descending artery (LAD) occlusion. Hemodyamics, infarct size, and myocardial function were assessed at baseline and after 1 month. Morphologic analysis revealed that labeled MSCs migrated in the peri-infarct region, resulting in smaller infarct size (32 ± 7 vs. 19 ± 7%, p = 0.01), higher fractional area shortening (23 ± 3 vs. 34.0 ± 7%, p = 0.001), lower left ventricular end diastolic pressure (18.7 ± 5 vs. 10.2 ± 4 mmHg, p = 0.02) and higher +dp/dt (4,570 ± 540 vs. 6,742 ± 700 mmHg/s, p = 0.03) during inotropic stimulation. Systemic intravenous delivery of MSCs to pigs limits myocardial infarct size and is an attractive approach for tissue repair." @default.
- W1965020866 created "2016-06-24" @default.
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- W1965020866 date "2007-02-01" @default.
- W1965020866 modified "2023-09-27" @default.
- W1965020866 title "Intravenous Delivery of Autologous Mesenchymal Stem Cells Limits Infarct Size and Improves Left Ventricular Function in The Infarcted Porcine Heart" @default.
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- W1965020866 doi "https://doi.org/10.1089/scd.2006.0089" @default.
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