FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965026465> ?p ?o ?g. }

• W1965026465 endingPage "1305" @default.
• W1965026465 startingPage "1296" @default.
• W1965026465 abstract "We previously identified a potent small-molecule human immunodeficiency virus type 1 (HIV-1) fusion inhibitor, termed ADS-J1, and hypothesized that it mainly targeted the hydrophobic pocket in the gp41 N-terminal heptad repeat (NHR) trimer. However, this hypothesis has been challenged by the fact that ADS-J1 cannot induce drug-resistance mutation in the gp41 pocket region. Therefore, we show herein that HIV-1 mutants resistant to T2635, a peptide derived from the gp41 C-terminal heptad repeat (CHR) region with pocket-binding domain (PBD), were also resistant to ADS-J1. We also show that pseudoviruses with mutations at positions 64 and 67 in the gp41 pocket region were highly resistant to ADS-J1 and C34, another CHR-peptide with PBD, but relatively sensitive to T20, a CHR-peptide without PBD. ADS-J1 could effectively bind to N36Fd, a mimic of the gp41 NHR-trimer with pocket exposed, and block binding of C34 to N36Fd trimer to form six-helix bundle (6-HB). However, ADS-J1 was less effective in binding to N36Fd trimer with mutations in the gp41 pocket region, such as N36(Q64A)Fd, N36(Q64L)Fd, N36(A67G)Fd, N36(A67S)Fd, and N36(Q66R)Fd, as well as less effective in blocking 6-HB formation between C34 and these mutant N36Fd trimers. These results confirm that ADS-J1 mainly targets the pocket region in the HIV-1 gp41 NHR trimer and suggest that it could be used as a lead for developing small-molecule HIV fusion inhibitors and as a molecule probe for studying the mechanisms of gp41-mediated membrane fusion." @default.
• W1965026465 created "2016-06-24" @default.
• W1965026465 creator A5016005172 @default.
• W1965026465 creator A5023492006 @default.
• W1965026465 creator A5038868099 @default.
• W1965026465 creator A5053960511 @default.
• W1965026465 creator A5065582452 @default.
• W1965026465 creator A5069302796 @default.
• W1965026465 creator A5080802367 @default.
• W1965026465 creator A5082593998 @default.
• W1965026465 creator A5085028455 @default.
• W1965026465 creator A5087473572 @default.
• W1965026465 creator A5088170766 @default.
• W1965026465 date "2014-05-01" @default.
• W1965026465 modified "2023-10-18" @default.
• W1965026465 title "ADS-J1 inhibits HIV-1 infection and membrane fusion by targeting the highly conserved pocket in the gp41 NHR-trimer" @default.
• W1965026465 cites W1895363198 @default.
• W1965026465 cites W1965049187 @default.
• W1965026465 cites W1965998957 @default.
• W1965026465 cites W1969541174 @default.
• W1965026465 cites W1975442784 @default.
• W1965026465 cites W1978425774 @default.
• W1965026465 cites W1993729293 @default.
• W1965026465 cites W1998885242 @default.
• W1965026465 cites W2000885937 @default.
• W1965026465 cites W2005780220 @default.
• W1965026465 cites W2010441540 @default.
• W1965026465 cites W2010566560 @default.
• W1965026465 cites W2027738518 @default.
• W1965026465 cites W2030648131 @default.
• W1965026465 cites W2033757712 @default.
• W1965026465 cites W2035648221 @default.
• W1965026465 cites W2036656105 @default.
• W1965026465 cites W2036796496 @default.
• W1965026465 cites W2038063067 @default.
• W1965026465 cites W2039492946 @default.
• W1965026465 cites W2048336729 @default.
• W1965026465 cites W2056949060 @default.
• W1965026465 cites W2063701397 @default.
• W1965026465 cites W2076091964 @default.
• W1965026465 cites W2084020395 @default.
• W1965026465 cites W2085739552 @default.
• W1965026465 cites W2091055028 @default.
• W1965026465 cites W2091847883 @default.
• W1965026465 cites W2096950500 @default.
• W1965026465 cites W2097137007 @default.
• W1965026465 cites W2097314439 @default.
• W1965026465 cites W2099026239 @default.
• W1965026465 cites W2111610276 @default.
• W1965026465 cites W2111734288 @default.
• W1965026465 cites W2113396991 @default.
• W1965026465 cites W2130167865 @default.
• W1965026465 cites W2141735242 @default.
• W1965026465 cites W2146478787 @default.
• W1965026465 cites W2154764173 @default.
• W1965026465 cites W2158946081 @default.
• W1965026465 cites W2172113588 @default.
• W1965026465 cites W4237410627 @default.
• W1965026465 doi "https://doi.org/10.1016/j.bbamem.2013.12.022" @default.
• W1965026465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24388952" @default.
• W1965026465 hasPublicationYear "2014" @default.
• W1965026465 type Work @default.
• W1965026465 sameAs 1965026465 @default.
• W1965026465 citedByCount "26" @default.
• W1965026465 countsByYear W19650264652015 @default.
• W1965026465 countsByYear W19650264652016 @default.
• W1965026465 countsByYear W19650264652017 @default.
• W1965026465 countsByYear W19650264652018 @default.
• W1965026465 countsByYear W19650264652019 @default.
• W1965026465 countsByYear W19650264652021 @default.
• W1965026465 countsByYear W19650264652022 @default.
• W1965026465 countsByYear W19650264652023 @default.
• W1965026465 crossrefType "journal-article" @default.
• W1965026465 hasAuthorship W1965026465A5016005172 @default.
• W1965026465 hasAuthorship W1965026465A5023492006 @default.
• W1965026465 hasAuthorship W1965026465A5038868099 @default.
• W1965026465 hasAuthorship W1965026465A5053960511 @default.
• W1965026465 hasAuthorship W1965026465A5065582452 @default.
• W1965026465 hasAuthorship W1965026465A5069302796 @default.
• W1965026465 hasAuthorship W1965026465A5080802367 @default.
• W1965026465 hasAuthorship W1965026465A5082593998 @default.
• W1965026465 hasAuthorship W1965026465A5085028455 @default.
• W1965026465 hasAuthorship W1965026465A5087473572 @default.
• W1965026465 hasAuthorship W1965026465A5088170766 @default.
• W1965026465 hasBestOaLocation W19650264651 @default.
• W1965026465 hasConcept C103038307 @default.
• W1965026465 hasConcept C104317684 @default.
• W1965026465 hasConcept C107824862 @default.
• W1965026465 hasConcept C122146531 @default.
• W1965026465 hasConcept C12554922 @default.
• W1965026465 hasConcept C143065580 @default.
• W1965026465 hasConcept C147483822 @default.
• W1965026465 hasConcept C153911025 @default.
• W1965026465 hasConcept C167625842 @default.
• W1965026465 hasConcept C178790620 @default.
• W1965026465 hasConcept C185592680 @default.
• W1965026465 hasConcept C195616568 @default.
• W1965026465 hasConcept C2776258796 @default.

• next