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- W196503346 abstract "Glycation is the nonenzymatic reaction of glucose, α-oxoaldehydes, and other saccharide derivatives with proteins, nucleotides, and lipids. It involves a complex series of parallel and sequential reactions, often collectively termed “the Maillard reaction,” that form many different adducts, some of which are fluorescent and colored “browning pigments.” Most studies in diabetes are of glycation of proteins only, but glycation of guanyl nucleotides and basic phospholipids also occurs. The polyol pathway is a two-step metabolic pathway in the cytosol of cells that converts glucose to sorbitol and converts sorbitol to fructose. These two enzymatic reactions are catalyzed by aldose reductase (ALR2, EC 1.1.1.21) and sorbitol dehydrogenase (SDH, EC 1.1.1.21), respectively. It becomes increasingly important as a fate for glucose metabolism with increasing severity of intracellular hyperglycemia." @default.
- W196503346 created "2016-06-24" @default.
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- W196503346 date "2004-01-01" @default.
- W196503346 modified "2023-09-27" @default.
- W196503346 title "Glycation- and/or Polyol Pathway-Inducing Complications" @default.
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- W196503346 doi "https://doi.org/10.1016/b0-12-475570-4/01448-7" @default.
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