Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965041031> ?p ?o ?g. }
- W1965041031 endingPage "3479" @default.
- W1965041031 startingPage "3474" @default.
- W1965041031 abstract "Lutein, a dihydroxy derivative of alpha-carotene (beta,epsilon-carotene), is the most abundant carotenoid in photosynthetic plant tissues where it plays important roles in light-harvesting complex-II structure and function. The synthesis of lutein from lycopene requires at least four distinct enzymatic reactions: beta- and epsilon-ring cyclizations and hydroxylation of each ring at the C-3 position. Three carotenoid hydroxylases have already been identified in Arabidopsis, two nonheme diiron beta-ring monooxygenases (the B1 and B2 loci) that primarily catalyze hydroxylation of the beta-ring of beta,beta-carotenoids and one heme-containing monooxygenase (CYP97C1, the LUT1 locus) that catalyzes hydroxylation of the epsilon-ring of beta,epsilon-carotenoids. In this study, we demonstrate that Arabidopsis CYP97A3 (the LUT5 locus) encodes a fourth carotenoid hydroxylase with major in vivo activity toward the beta-ring of alpha-carotene (beta,epsilon-carotene) and minor activity on the beta-rings of beta-carotene (beta,beta-carotene). A cyp97a3-null allele, lut5-1, causes an accumulation of alpha-carotene at a level equivalent to beta-carotene in wild type, which is stably incorporated into photosystems, and a 35% reduction in beta-carotene-derived xanthophylls. That lut5-1 still produces 80% of wild-type lutein levels, indicating at least one of the other carotene hydroxylases, can partially compensate for the loss of CYP97A3 activity. From these data, we propose a model for the preferred pathway for lutein synthesis in plants: ring cyclizations to form alpha-carotene, beta-ring hydroxylation of alpha-carotene by CYP97A3 to produce zeinoxanthin, followed by epsilon-ring hydroxylation of zeinoxanthin by CYP97C1 to produce lutein." @default.
- W1965041031 created "2016-06-24" @default.
- W1965041031 creator A5037889583 @default.
- W1965041031 creator A5067641292 @default.
- W1965041031 date "2006-02-21" @default.
- W1965041031 modified "2023-10-17" @default.
- W1965041031 title "Defining the primary route for lutein synthesis in plants: The role of <i>Arabidopsis</i> carotenoid β-ring hydroxylase CYP97A3" @default.
- W1965041031 cites W1247723589 @default.
- W1965041031 cites W1969738934 @default.
- W1965041031 cites W1981882377 @default.
- W1965041031 cites W1992236822 @default.
- W1965041031 cites W1998610748 @default.
- W1965041031 cites W1999626737 @default.
- W1965041031 cites W2014911581 @default.
- W1965041031 cites W2015907903 @default.
- W1965041031 cites W2017364820 @default.
- W1965041031 cites W2018939640 @default.
- W1965041031 cites W2023173927 @default.
- W1965041031 cites W2032585343 @default.
- W1965041031 cites W2034876099 @default.
- W1965041031 cites W2041523103 @default.
- W1965041031 cites W2043318790 @default.
- W1965041031 cites W2048342700 @default.
- W1965041031 cites W2060200492 @default.
- W1965041031 cites W2066330705 @default.
- W1965041031 cites W2070098436 @default.
- W1965041031 cites W2070119008 @default.
- W1965041031 cites W2076512725 @default.
- W1965041031 cites W2079670340 @default.
- W1965041031 cites W2081225373 @default.
- W1965041031 cites W2086701309 @default.
- W1965041031 cites W2094394089 @default.
- W1965041031 cites W2102452195 @default.
- W1965041031 cites W2104180764 @default.
- W1965041031 cites W2109252416 @default.
- W1965041031 cites W2117917400 @default.
- W1965041031 cites W2129095580 @default.
- W1965041031 cites W2135777982 @default.
- W1965041031 cites W2135974219 @default.
- W1965041031 cites W2139213155 @default.
- W1965041031 cites W2153862518 @default.
- W1965041031 cites W2166979580 @default.
- W1965041031 cites W321181288 @default.
- W1965041031 cites W4211056566 @default.
- W1965041031 cites W4243286400 @default.
- W1965041031 doi "https://doi.org/10.1073/pnas.0511207103" @default.
- W1965041031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1413914" @default.
- W1965041031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16492736" @default.
- W1965041031 hasPublicationYear "2006" @default.
- W1965041031 type Work @default.
- W1965041031 sameAs 1965041031 @default.
- W1965041031 citedByCount "224" @default.
- W1965041031 countsByYear W19650410312012 @default.
- W1965041031 countsByYear W19650410312013 @default.
- W1965041031 countsByYear W19650410312014 @default.
- W1965041031 countsByYear W19650410312015 @default.
- W1965041031 countsByYear W19650410312016 @default.
- W1965041031 countsByYear W19650410312017 @default.
- W1965041031 countsByYear W19650410312018 @default.
- W1965041031 countsByYear W19650410312019 @default.
- W1965041031 countsByYear W19650410312020 @default.
- W1965041031 countsByYear W19650410312021 @default.
- W1965041031 countsByYear W19650410312022 @default.
- W1965041031 countsByYear W19650410312023 @default.
- W1965041031 crossrefType "journal-article" @default.
- W1965041031 hasAuthorship W1965041031A5037889583 @default.
- W1965041031 hasAuthorship W1965041031A5067641292 @default.
- W1965041031 hasBestOaLocation W19650410311 @default.
- W1965041031 hasConcept C104317684 @default.
- W1965041031 hasConcept C125575132 @default.
- W1965041031 hasConcept C143065580 @default.
- W1965041031 hasConcept C181199279 @default.
- W1965041031 hasConcept C185592680 @default.
- W1965041031 hasConcept C2778411929 @default.
- W1965041031 hasConcept C2779491563 @default.
- W1965041031 hasConcept C2781109383 @default.
- W1965041031 hasConcept C28781525 @default.
- W1965041031 hasConcept C55493867 @default.
- W1965041031 hasConcept C71240020 @default.
- W1965041031 hasConcept C86803240 @default.
- W1965041031 hasConceptScore W1965041031C104317684 @default.
- W1965041031 hasConceptScore W1965041031C125575132 @default.
- W1965041031 hasConceptScore W1965041031C143065580 @default.
- W1965041031 hasConceptScore W1965041031C181199279 @default.
- W1965041031 hasConceptScore W1965041031C185592680 @default.
- W1965041031 hasConceptScore W1965041031C2778411929 @default.
- W1965041031 hasConceptScore W1965041031C2779491563 @default.
- W1965041031 hasConceptScore W1965041031C2781109383 @default.
- W1965041031 hasConceptScore W1965041031C28781525 @default.
- W1965041031 hasConceptScore W1965041031C55493867 @default.
- W1965041031 hasConceptScore W1965041031C71240020 @default.
- W1965041031 hasConceptScore W1965041031C86803240 @default.
- W1965041031 hasIssue "9" @default.
- W1965041031 hasLocation W19650410311 @default.
- W1965041031 hasLocation W19650410312 @default.
- W1965041031 hasLocation W19650410313 @default.
- W1965041031 hasLocation W19650410314 @default.
- W1965041031 hasOpenAccess W1965041031 @default.