Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965056458> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1965056458 endingPage "A27" @default.
- W1965056458 startingPage "A27.1" @default.
- W1965056458 abstract "<h3>Background</h3> Syphilis, a sexually transmitted disease caused by spirochetal bacterium Treponema pallidum, can progress to affect central nervous system, causing neurosyphilis. While many neurosyphilis patients may be asymptomatic, some patients can develop severe neurological and psychiatric symptoms. Accumulating evidence suggest that skin lesions and clinical symptoms of early syphilis patients result from host immune and inflammatory responses. However, very little is known about the immune components in neurosyphilis. <h3>Methodology/Principal Findings</h3> In the present study, we perform a comprehensive and comparative analysis of regulatory T cells (Tregs) between 102 neurosyphilis patients and 431 syphilis patients without neurological involvement. We found secondary and serofast patients had increased Treg percentage, suppressive function and TGF-β levels in peripheral blood compared to healthy donors and serum Rapid Plasma Reagin (RPR) titers were positively correlated with Treg numbers in these patients. Neurosyphilis patients had higher Treg frequency in peripheral blood than those of syphilis patients without neurological involvement. Importantly, CD4+ T cells were increased and predominated in cerebrospinal fluid (CSF) of both asymptomatic and symptomatic neurosyphilis patients. Interestingly, a significant decrease in CSF CD4+ CD25 high Treg percentage was observed in symptomatic neurosyphilis patients compared to those of asymptomatic neurosyphilis patients, which may be associated with low CSF TGF-β levels. <h3>Conclusions</h3> Our findings suggest that neurological progression in syphilis patients may be associated with an enhanced systemic Treg response and an increased local CD4+ T cell infiltration. A decrease in Treg frequency in CSF of symptomatic neurosyphilis patients indicates that immune-mediate tissue damage might be involved in the development of neurological symptoms." @default.
- W1965056458 created "2016-06-24" @default.
- W1965056458 creator A5045067203 @default.
- W1965056458 creator A5046267411 @default.
- W1965056458 creator A5058590640 @default.
- W1965056458 creator A5080314630 @default.
- W1965056458 creator A5089681398 @default.
- W1965056458 date "2013-07-01" @default.
- W1965056458 modified "2023-09-27" @default.
- W1965056458 title "O01.3 Regulatory T Cells in Peripheral Blood and Cerebrospinal Fluid of Syphilis Patients with and Without Neurological Involvement: A Comprehensive and Comparative Study" @default.
- W1965056458 doi "https://doi.org/10.1136/sextrans-2013-051184.0085" @default.
- W1965056458 hasPublicationYear "2013" @default.
- W1965056458 type Work @default.
- W1965056458 sameAs 1965056458 @default.
- W1965056458 citedByCount "0" @default.
- W1965056458 crossrefType "journal-article" @default.
- W1965056458 hasAuthorship W1965056458A5045067203 @default.
- W1965056458 hasAuthorship W1965056458A5046267411 @default.
- W1965056458 hasAuthorship W1965056458A5058590640 @default.
- W1965056458 hasAuthorship W1965056458A5080314630 @default.
- W1965056458 hasAuthorship W1965056458A5089681398 @default.
- W1965056458 hasBestOaLocation W19650564581 @default.
- W1965056458 hasConcept C126322002 @default.
- W1965056458 hasConcept C137916694 @default.
- W1965056458 hasConcept C203014093 @default.
- W1965056458 hasConcept C2776687281 @default.
- W1965056458 hasConcept C2776983459 @default.
- W1965056458 hasConcept C2777910003 @default.
- W1965056458 hasConcept C2779651940 @default.
- W1965056458 hasConcept C2780187896 @default.
- W1965056458 hasConcept C2781319584 @default.
- W1965056458 hasConcept C2909760446 @default.
- W1965056458 hasConcept C3013748606 @default.
- W1965056458 hasConcept C71924100 @default.
- W1965056458 hasConcept C8891405 @default.
- W1965056458 hasConceptScore W1965056458C126322002 @default.
- W1965056458 hasConceptScore W1965056458C137916694 @default.
- W1965056458 hasConceptScore W1965056458C203014093 @default.
- W1965056458 hasConceptScore W1965056458C2776687281 @default.
- W1965056458 hasConceptScore W1965056458C2776983459 @default.
- W1965056458 hasConceptScore W1965056458C2777910003 @default.
- W1965056458 hasConceptScore W1965056458C2779651940 @default.
- W1965056458 hasConceptScore W1965056458C2780187896 @default.
- W1965056458 hasConceptScore W1965056458C2781319584 @default.
- W1965056458 hasConceptScore W1965056458C2909760446 @default.
- W1965056458 hasConceptScore W1965056458C3013748606 @default.
- W1965056458 hasConceptScore W1965056458C71924100 @default.
- W1965056458 hasConceptScore W1965056458C8891405 @default.
- W1965056458 hasIssue "Suppl 1" @default.
- W1965056458 hasLocation W19650564581 @default.
- W1965056458 hasOpenAccess W1965056458 @default.
- W1965056458 hasPrimaryLocation W19650564581 @default.
- W1965056458 hasRelatedWork W1608267744 @default.
- W1965056458 hasRelatedWork W1965056458 @default.
- W1965056458 hasRelatedWork W1971078639 @default.
- W1965056458 hasRelatedWork W2009081256 @default.
- W1965056458 hasRelatedWork W2015960220 @default.
- W1965056458 hasRelatedWork W2051065778 @default.
- W1965056458 hasRelatedWork W2130155882 @default.
- W1965056458 hasRelatedWork W2133922140 @default.
- W1965056458 hasRelatedWork W2136414164 @default.
- W1965056458 hasRelatedWork W2900221271 @default.
- W1965056458 hasVolume "89" @default.
- W1965056458 isParatext "false" @default.
- W1965056458 isRetracted "false" @default.
- W1965056458 magId "1965056458" @default.
- W1965056458 workType "article" @default.