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• W1965069752 abstract "Ribosomes are molecular machines that function in polyribosome complexes to translate genetic information, guide the synthesis of polypeptides, and modulate the folding of nascent proteins. Here, we report a surprising function for polyribosomes as a result of a systematic examination of the assembly of a large ribonucleoprotein complex, the vault particle. Structural and functional evidence points to a model of vault assembly whereby the polyribosome acts like a 3D nanoprinter to direct the ordered translation and assembly of the multi-subunit vault homopolymer, a process which we refer to as polyribosome templating. Structure-based mutagenesis and cell-free in vitro expression studies further demonstrated the critical importance of the polyribosome in vault assembly. Polyribosome templating prevents chaos by ensuring efficiency and order in the production of large homopolymeric protein structures in the crowded cellular environment and might explain the origin of many polyribosome-associated molecular assemblies inside the cell." @default.
• W1965069752 created "2016-06-24" @default.
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• W1965069752 date "2014-10-30" @default.
• W1965069752 modified "2023-09-29" @default.
• W1965069752 title "Polyribosomes Are Molecular 3D Nanoprinters That Orchestrate the Assembly of Vault Particles" @default.
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• W1965069752 doi "https://doi.org/10.1021/nn504778h" @default.
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