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• W1965075408 abstract "The important cardiovascular regulator renin contains a strong in vitro enhancer 2.7 kb upstream of its gene. Here we tested the in vivo role of the mouse Ren-1c enhancer. In renin-expressing As4.1 cells stably transfected with Ren-1c promoter with or without enhancer, expression of linked β-geo reporter, stable expression, and colony formation were dependent on the presence of the enhancer. We then generated mice carrying a targeted deletion of the enhancer (REKO mice) and found marked depletion of renin in renal juxtaglomerular and submandibular ductal cells, as well as hyperplasia of macula densa cells. Plasma creatinine was increased, but electrolytes were normal. Male REKO mice implanted with telemetry devices had 9 ± 1 mm Hg lower mean arterial pressure (p" @default.
• W1965075408 created "2016-06-24" @default.
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• W1965075408 date "2006-08-08" @default.
• W1965075408 modified "2023-10-16" @default.
• W1965075408 title "Renin Enhancer Is Critical for Control of Renin Gene Expression and Cardiovascular Function" @default.
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• W1965075408 doi "https://doi.org/10.1074/jbc.m605720200" @default.
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