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- W1965080136 endingPage "e1003951" @default.
- W1965080136 startingPage "e1003951" @default.
- W1965080136 abstract "Polycomb group (PcG) proteins are essential for the repression of key factors during early development. In Drosophila, the polycomb repressive complexes (PRC) associate with defined polycomb response DNA elements (PREs). In mammals, however, the mechanisms underlying polycomb recruitment at targeted loci are poorly understood. We have used an in vivo approach to identify DNA sequences of importance for the proper recruitment of polycomb proteins at the HoxD locus. We report that various genomic re-arrangements of the gene cluster do not strongly affect PRC2 recruitment and that relatively small polycomb interacting sequences appear necessary and sufficient to confer polycomb recognition and targeting to ectopic loci. In addition, a high GC content, while not sufficient to recruit PRC2, may help its local spreading. We discuss the importance of PRC2 recruitment over Hox gene clusters in embryonic stem cells, for their subsequent coordinated transcriptional activation during development." @default.
- W1965080136 created "2016-06-24" @default.
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- W1965080136 date "2013-11-07" @default.
- W1965080136 modified "2023-10-18" @default.
- W1965080136 title "A Genetic Approach to the Recruitment of PRC2 at the HoxD Locus" @default.
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- W1965080136 doi "https://doi.org/10.1371/journal.pgen.1003951" @default.
- W1965080136 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3820793" @default.
- W1965080136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24244202" @default.
- W1965080136 hasPublicationYear "2013" @default.
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