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- W196510367 abstract "This chapter reviews the study of primary brain tumors and paraneoplastic neurologic syndromes using defective herpes simplex viral (HSV) vectors and adeno-associated virus (AAV) vectors. The AAV vector is similar to the defective HSV vector in that it contains only viral recognition sequences but no viral genes. Adenovirus is used as a helper virus to provide replication proteins. The AAV vector is packaged into an AAV coat, which is distinct from the helper adenovirus. The ability to generate a stock of AAV vector free of helper adenovirus makes the AAV vector well suited to serve as a therapeutic agent. These viruses can enter the cell nucleus and express foreign genes in the absence of active cell division so that even nondividing tumor cells are potential targets of these vectors. Tumor-suppressor genes encode for proteins that regulate normal cell functions including cell proliferation and differentiation. The loss of function of these proteins, either due to mutation or deletion, has been associated with tumor formation. The p53 gene is a tumor-suppressor gene that is often found mutated or deleted in human cancers. Overexpression of mutant p53 protein is the most common genetic abnormality detected in human cancers and the p53 gene product has a central role in normal cell proliferation. The chapter also reviews the study of paraneoplastic syndromes including paraneoplastic encephalomyelitis (PEM), paraneoplastic cerebellar degeneration, and paraneoplastic opsoclonus-myoclonus, and the concept of gene transfer. DNA viral vectors are versatile tools that can be as potential therapeutic agents in the treatment of tumors of the nervous system and also in the study of other neurologic disorders. These vectors are used to gain insights into the pathogenesis of some paraneoplastic neurologic syndromes and the ability to transfer genes using DNA can possibly used for treating cancer in the future. =" @default.
- W196510367 created "2016-06-24" @default.
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- W196510367 date "1995-01-01" @default.
- W196510367 modified "2023-09-24" @default.
- W196510367 title "Transfer and Expression of Antioncogenes and Paraneoplastic Genes in Normal and Neoplastic Cells in Vitro and in Vivo" @default.
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- W196510367 doi "https://doi.org/10.1016/b978-012397570-6/50018-6" @default.
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