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• W1965110215 abstract "Troglitazone was discovered by Sankyo Co. Ltd, in 1982. It represents a new class of antidiabetic agents targeted at ameliorating insulin resistance in type 2 diabetes patients. It is unrelated both chemically and functionally to the sulfonylurea and biguanide classes of oral antidiabetic agents. Troglitazone was found to reverse insulin resistance by its ability to increase insulinstimulated glucose utilization and reduce hepatic glucose production. It has also been suggested that troglitazone exerts its insulin-enhancing effects by interacting with peroxisome proliferation activated receptor γ (PPARγ) regulated gene transcription." @default.
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• W1965110215 date "1998-02-01" @default.
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• W1965110215 title "Troglitazone — a novel antidiabetic drug for treating insulin resistance" @default.
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• W1965110215 doi "https://doi.org/10.1016/s1359-6446(97)01115-x" @default.
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