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- W1965119458 abstract "The monoclonal IgM-κ and IgA-κ proteins from the serum of patient CM were initially shown to share identical idiotypic determinants (Fair et al., 1976). It was also shown that a portion of the IgG fraction from this patient's serum also contained the reacting idiotypic component. In this report we describe the purification to homogeneity of the IgG monoclonal protein from a later serum sample and show that this isolated IgG monoclonal protein shares identical idiotypic determinants with both the monoclonal IgM and IgA proteins. Our conclusions were based on four separate double antibody competitive equilibrium radioimmunoassays. Sequential changes in the levels of both IgG and IgA over a period of 75 months indicated that these two paraproteins fluctuated in parallel to one another during this period of time and were not significantly influenced by Chlorambucil therapy. Previous immunofluorescent data and the establishment of the structural identities of IgG to IgM and IgA suggest that both pathways of immunoglobulin differentiation (i.e. IgM → IgA and IgM → IgG) may be occurring in patient CM. The differences in the expression of these classes of immunoglobulin observed over the 75-month period may reflect the gradual maturation of these developmental pathways of antibody forming cells." @default.
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- W1965119458 date "1980-08-01" @default.
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- W1965119458 title "Sharing of identical idiotypic determinants among the monoclonal IgG, IgA and IgM in a single individual" @default.
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- W1965119458 doi "https://doi.org/10.1016/0161-5890(80)90100-5" @default.
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