FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965120013> ?p ?o ?g. }

• W1965120013 endingPage "275" @default.
• W1965120013 startingPage "265" @default.
• W1965120013 abstract "In a 4 year clinical trial in 202 postmenopausal osteoporotic women receiving NaF at 75 mg/day or placebo (both groups received supplementary calcium at 1500 mg/day), we found (N Engl J Med 322:801, 1990) that NaF increased bone mineral density in the lumbar spine (LS-BMD) substantially but did not decrease vertebral fracture rate (VFR), and it increased the nonvertebral fracture rate. Additional analyses and extended observations are now available on 50 women from the NaF group followed for up to 6 years of treatment. In these women, LS-BMD increased linearly over the 6 years (median rate, 8.7%/year or 0.063 g/cm2/year). Because during the 4 year trial the NaF dosage was decreased (because of side effects) in 54 of the 101 women randomized to NaF, dose-response relationships could be evaluated. For the entire study population, serum F level correlated directly with increase in LS-BMD (r = 0.61, P < 0.001). When individual person-years of observation were grouped by deciles of LS-BMD, VFR (per 100 person-years) decreased to a nadir of 24 as mean LS-BMD for the group increased from 0.6 to 1.2 g/cm2 and then doubled to 52 in the group with mean LS-BMD of 1.6 g/cm2. Multivariate analyses and inspection of three-dimensional plots revealed a complex pattern in which VFR was influenced by interaction of several variables. When the effects of LS-BMD, changes in LS-BMD, and serum F were assessed simultaneously, VFR was seen to decrease with increasing LS-BMD except when the higher LS-BMD was associated with rapid rate of increase in LS-BMD or a large increase from baseline serum F. For some patients (noncompliers or nonresponders), serum F or LS-BMD failed to increase. Thus, it is possible that lower dosages of NaF produce moderate decreases in VFR." @default.
• W1965120013 created "2016-06-24" @default.
• W1965120013 creator A5007657072 @default.
• W1965120013 creator A5010835977 @default.
• W1965120013 creator A5015517215 @default.
• W1965120013 creator A5020440068 @default.
• W1965120013 creator A5021994034 @default.
• W1965120013 creator A5025543139 @default.
• W1965120013 creator A5044425707 @default.
• W1965120013 creator A5090023242 @default.
• W1965120013 date "1994-02-01" @default.
• W1965120013 modified "2023-10-04" @default.
• W1965120013 title "Clinical trial of fluoride therapy in postmenopausal osteoporotic women: Extended observations and additional analysis" @default.
• W1965120013 cites W1826010384 @default.
• W1965120013 cites W1968418396 @default.
• W1965120013 cites W1977763789 @default.
• W1965120013 cites W1979353935 @default.
• W1965120013 cites W1979471317 @default.
• W1965120013 cites W1986626030 @default.
• W1965120013 cites W1995004590 @default.
• W1965120013 cites W2002491837 @default.
• W1965120013 cites W2008568166 @default.
• W1965120013 cites W2018089017 @default.
• W1965120013 cites W2018256319 @default.
• W1965120013 cites W2018344668 @default.
• W1965120013 cites W2029419426 @default.
• W1965120013 cites W2035710150 @default.
• W1965120013 cites W2042009130 @default.
• W1965120013 cites W2053530406 @default.
• W1965120013 cites W2062934439 @default.
• W1965120013 cites W2065466778 @default.
• W1965120013 cites W2068940638 @default.
• W1965120013 cites W2078406992 @default.
• W1965120013 cites W2078423621 @default.
• W1965120013 cites W2097350795 @default.
• W1965120013 cites W2102024055 @default.
• W1965120013 cites W2112635953 @default.
• W1965120013 cites W2163445297 @default.
• W1965120013 cites W2168634441 @default.
• W1965120013 cites W2224175626 @default.
• W1965120013 cites W2336000481 @default.
• W1965120013 cites W2336678594 @default.
• W1965120013 cites W2337197041 @default.
• W1965120013 cites W2337977161 @default.
• W1965120013 cites W2411088572 @default.
• W1965120013 cites W4297742609 @default.
• W1965120013 doi "https://doi.org/10.1002/jbmr.5650090216" @default.
• W1965120013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8140940" @default.
• W1965120013 hasPublicationYear "1994" @default.
• W1965120013 type Work @default.
• W1965120013 sameAs 1965120013 @default.
• W1965120013 citedByCount "136" @default.
• W1965120013 countsByYear W19651200132012 @default.
• W1965120013 countsByYear W19651200132014 @default.
• W1965120013 countsByYear W19651200132015 @default.
• W1965120013 countsByYear W19651200132016 @default.
• W1965120013 countsByYear W19651200132018 @default.
• W1965120013 countsByYear W19651200132020 @default.
• W1965120013 crossrefType "journal-article" @default.
• W1965120013 hasAuthorship W1965120013A5007657072 @default.
• W1965120013 hasAuthorship W1965120013A5010835977 @default.
• W1965120013 hasAuthorship W1965120013A5015517215 @default.
• W1965120013 hasAuthorship W1965120013A5020440068 @default.
• W1965120013 hasAuthorship W1965120013A5021994034 @default.
• W1965120013 hasAuthorship W1965120013A5025543139 @default.
• W1965120013 hasAuthorship W1965120013A5044425707 @default.
• W1965120013 hasAuthorship W1965120013A5090023242 @default.
• W1965120013 hasConcept C126322002 @default.
• W1965120013 hasConcept C126894567 @default.
• W1965120013 hasConcept C142724271 @default.
• W1965120013 hasConcept C168563851 @default.
• W1965120013 hasConcept C204787440 @default.
• W1965120013 hasConcept C27081682 @default.
• W1965120013 hasConcept C2776541429 @default.
• W1965120013 hasConcept C2776886416 @default.
• W1965120013 hasConcept C2779329777 @default.
• W1965120013 hasConcept C2908647359 @default.
• W1965120013 hasConcept C3018603563 @default.
• W1965120013 hasConcept C71924100 @default.
• W1965120013 hasConcept C99454951 @default.
• W1965120013 hasConceptScore W1965120013C126322002 @default.
• W1965120013 hasConceptScore W1965120013C126894567 @default.
• W1965120013 hasConceptScore W1965120013C142724271 @default.
• W1965120013 hasConceptScore W1965120013C168563851 @default.
• W1965120013 hasConceptScore W1965120013C204787440 @default.
• W1965120013 hasConceptScore W1965120013C27081682 @default.
• W1965120013 hasConceptScore W1965120013C2776541429 @default.
• W1965120013 hasConceptScore W1965120013C2776886416 @default.
• W1965120013 hasConceptScore W1965120013C2779329777 @default.
• W1965120013 hasConceptScore W1965120013C2908647359 @default.
• W1965120013 hasConceptScore W1965120013C3018603563 @default.
• W1965120013 hasConceptScore W1965120013C71924100 @default.
• W1965120013 hasConceptScore W1965120013C99454951 @default.
• W1965120013 hasIssue "2" @default.
• W1965120013 hasLocation W19651200131 @default.
• W1965120013 hasLocation W19651200132 @default.
• W1965120013 hasOpenAccess W1965120013 @default.
• W1965120013 hasPrimaryLocation W19651200131 @default.

• next