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- W1965121349 abstract "Abstract Dihydroartemisinin (DHA), a semi-synthetic derivative of the herb artemisinin, has shown commendable bioactivity. In this paper, a novel dihydroartemisinin-organogermanium (DHA-Ge) compound was synthesized, characterized and its potential anti-tumor activity was evaluated by various methods. MTT results demonstrated that DHA-Ge could effectively inhibit the proliferation of HepG2 cells and showed their dose-dependent properties. The IC 50 value of inhibition effect on HepG2 cells of DHA-Ge was 10.23 μg/ml which was lower than 39.44 μg/ml of DHA. Flow cytometric results suggested that DHA-Ge could induce apoptosis of HepG2 cells and the apoptosis rate was 20.26% after 24 h treatment with 56.8 μg/ml DHA-Ge concentration. Atomic force microscopy images showed that HepG2 cells were collapsed and the cell nucleus were fragmented after 24 h treatment. All these results together showed that the DHA-Ge possessed desirable synergetic enhanced anti-tumor effects and could be developed as a suitable tumor therapeutic agent." @default.
- W1965121349 created "2016-06-24" @default.
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- W1965121349 date "2014-11-01" @default.
- W1965121349 modified "2023-09-29" @default.
- W1965121349 title "Synthesis and synergetic anti-tumor activity evaluation of dihydroartemisinin-organogermanium(IV) compound" @default.
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- W1965121349 doi "https://doi.org/10.1016/j.bmcl.2014.09.048" @default.
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