FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965125909> ?p ?o ?g. }

• W1965125909 endingPage "87" @default.
• W1965125909 startingPage "77" @default.
• W1965125909 abstract "Cyclooxygenase (COX)-2 plays critical roles in tumorigenesis, tumor cell growth, and angiogenesis, and inhibiting the expression of COX-2 by gene therapy has showed promising prospects. Vectors are crucial for gene therapy. Polyamidoamine (PAMAM) dendrimers are one type of nano-vectors. In this study, we synthesized a generation 4 polyamidoamine (G4PAMAM) dendrimer/COX-2 antisense oligodeoxynucleotide complex (G4PAMAM/COX-2ASODN), determined the transfection rate of G4PAMAM/COX-2ASODN on cultured breast cancer cells, assessed the cell viability, cell cycle dynamics, and cell invasiveness after transfection, and investigated the effects of G4PAMAM/COX-2ASODN on the expression of COX-2 mRNA and protein and microvessel density (MVD) levels in the tumor tissues of a breast cancer nude mouse model. The results showed that G4PAMAM/COX-2ASODN had a high transfection rate, decreased the cell viability, induced apoptosis and G0/G1 cell cycle arrest, and suppressed cell invasiveness. After treatment with G4PAMAM/COX-2ASODN, the copy number of COX-2 mRNA and protein expression in the tumor tissue were decreased markedly, MVD in the tumor tissue was also decreased, and tumor growth was restrained (p<0. 05). We conclude that COX-2ASODN can be delivered into the cultured and transplanted breast cancer cells efficiently by G4PAMAM, can reduce the expression of COX-2 mRNA and protein, and can lower the MVD of tumor tissues. The G4PAMAM/COX-2ASODN complex has antitumor properties in vitro and in vivo." @default.
• W1965125909 created "2016-06-24" @default.
• W1965125909 creator A5005976410 @default.
• W1965125909 creator A5022160487 @default.
• W1965125909 creator A5043662232 @default.
• W1965125909 creator A5052538583 @default.
• W1965125909 creator A5059040206 @default.
• W1965125909 creator A5072316432 @default.
• W1965125909 creator A5082102743 @default.
• W1965125909 date "2012-02-01" @default.
• W1965125909 modified "2023-10-12" @default.
• W1965125909 title "Antitumor Effect of a Generation 4 Polyamidoamine Dendrimer/Cyclooxygenase-2 Antisense Oligodeoxynucleotide Complex on Breast Cancer<i>In Vitro</i>and<i>In Vivo</i>" @default.
• W1965125909 cites W1968324199 @default.
• W1965125909 cites W1972301619 @default.
• W1965125909 cites W1975833492 @default.
• W1965125909 cites W1976811878 @default.
• W1965125909 cites W1980101293 @default.
• W1965125909 cites W1982547903 @default.
• W1965125909 cites W1985126638 @default.
• W1965125909 cites W1989810681 @default.
• W1965125909 cites W1992620470 @default.
• W1965125909 cites W1994354502 @default.
• W1965125909 cites W1998372363 @default.
• W1965125909 cites W2001914176 @default.
• W1965125909 cites W2010655741 @default.
• W1965125909 cites W2011085652 @default.
• W1965125909 cites W2014955737 @default.
• W1965125909 cites W2015471235 @default.
• W1965125909 cites W2018115649 @default.
• W1965125909 cites W2018149682 @default.
• W1965125909 cites W2018728235 @default.
• W1965125909 cites W2018894464 @default.
• W1965125909 cites W2020755798 @default.
• W1965125909 cites W2021574571 @default.
• W1965125909 cites W2028868351 @default.
• W1965125909 cites W2041577133 @default.
• W1965125909 cites W2058252240 @default.
• W1965125909 cites W2063915751 @default.
• W1965125909 cites W2077325967 @default.
• W1965125909 cites W2077773545 @default.
• W1965125909 cites W2078963996 @default.
• W1965125909 cites W2081761148 @default.
• W1965125909 cites W2086069830 @default.
• W1965125909 cites W2097699954 @default.
• W1965125909 cites W2118855413 @default.
• W1965125909 cites W2125381755 @default.
• W1965125909 cites W2127558096 @default.
• W1965125909 cites W2142177142 @default.
• W1965125909 cites W2144144584 @default.
• W1965125909 cites W2146570123 @default.
• W1965125909 cites W2147156994 @default.
• W1965125909 cites W2149450175 @default.
• W1965125909 cites W2159973565 @default.
• W1965125909 cites W2301868394 @default.
• W1965125909 cites W2399319395 @default.
• W1965125909 cites W2488797276 @default.
• W1965125909 doi "https://doi.org/10.1089/cbr.2011.1028" @default.
• W1965125909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22242594" @default.
• W1965125909 hasPublicationYear "2012" @default.
• W1965125909 type Work @default.
• W1965125909 sameAs 1965125909 @default.
• W1965125909 citedByCount "8" @default.
• W1965125909 countsByYear W19651259092012 @default.
• W1965125909 countsByYear W19651259092013 @default.
• W1965125909 countsByYear W19651259092014 @default.
• W1965125909 countsByYear W19651259092020 @default.
• W1965125909 countsByYear W19651259092021 @default.
• W1965125909 countsByYear W19651259092022 @default.
• W1965125909 crossrefType "journal-article" @default.
• W1965125909 hasAuthorship W1965125909A5005976410 @default.
• W1965125909 hasAuthorship W1965125909A5022160487 @default.
• W1965125909 hasAuthorship W1965125909A5043662232 @default.
• W1965125909 hasAuthorship W1965125909A5052538583 @default.
• W1965125909 hasAuthorship W1965125909A5059040206 @default.
• W1965125909 hasAuthorship W1965125909A5072316432 @default.
• W1965125909 hasAuthorship W1965125909A5082102743 @default.
• W1965125909 hasConcept C121608353 @default.
• W1965125909 hasConcept C1491633281 @default.
• W1965125909 hasConcept C150903083 @default.
• W1965125909 hasConcept C153911025 @default.
• W1965125909 hasConcept C185592680 @default.
• W1965125909 hasConcept C190283241 @default.
• W1965125909 hasConcept C207001950 @default.
• W1965125909 hasConcept C2780394083 @default.
• W1965125909 hasConcept C29537977 @default.
• W1965125909 hasConcept C502942594 @default.
• W1965125909 hasConcept C53227056 @default.
• W1965125909 hasConcept C54009773 @default.
• W1965125909 hasConcept C54355233 @default.
• W1965125909 hasConcept C55493867 @default.
• W1965125909 hasConcept C555283112 @default.
• W1965125909 hasConcept C62112901 @default.
• W1965125909 hasConcept C81885089 @default.
• W1965125909 hasConcept C86803240 @default.
• W1965125909 hasConcept C96232424 @default.
• W1965125909 hasConceptScore W1965125909C121608353 @default.
• W1965125909 hasConceptScore W1965125909C1491633281 @default.
• W1965125909 hasConceptScore W1965125909C150903083 @default.

• next