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- W1965127680 abstract "The M-current ( I M ), comprised of Kv7 channels, is a voltage-activated K + conductance that plays a key role in the control of cell excitability. In hippocampal principal cells, I M controls action potential (AP) accommodation and contributes to the medium-duration afterhyperpolarization, but the role of I M in control of interneuron excitability remains unclear. Here, we investigated I M in hippocampal stratum oriens (SO) interneurons, both from wild-type and transgenic mice in which green fluorescent protein (GFP) was expressed in somatostatin-containing interneurons. Somatodendritic expression of Kv7.2 or Kv7.3 subunits was colocalized in a subset of GFP+ SO interneurons, corresponding to oriens-lacunosum moleculare (O-LM) cells. Under voltage clamp (VC) conditions at −30 mV, the Kv7 channel antagonists linopirdine/XE-991 abolished the I M amplitude present during relaxation from −30 to −50 mV and reduced the holding current ( I hold ). In addition, 0.5 m m tetraethylammonium reduced I M , suggesting that I M was composed of Kv7.2-containing channels. In contrast, the Kv7 channel opener retigabine increased I M amplitude and I hold . When strongly depolarized in VC, the linopirdine-sensitive outward current activated rapidly and comprised up to 20% of the total current. In current-clamp recordings from GFP+ SO cells, linopirdine induced depolarization and increased AP frequency, whereas retigabine induced hyperpolarization and arrested firing. In multicompartment O-LM interneuron models that incorporated I M , somatodendritic placement of Kv7 channels best reproduced experimentally measured I M . The models suggest that Kv3- and Kv7-mediated channels both rapidly activate during single APs; however, Kv3 channels control rapid repolarization of the AP, whereas Kv7 channels primarily control the interspike interval." @default.
- W1965127680 created "2016-06-24" @default.
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- W1965127680 date "2006-11-22" @default.
- W1965127680 modified "2023-10-18" @default.
- W1965127680 title "Somatodendritic Kv7/KCNQ/M Channels Control Interspike Interval in Hippocampal Interneurons" @default.
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- W1965127680 doi "https://doi.org/10.1523/jneurosci.3521-06.2006" @default.
- W1965127680 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6675427" @default.
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- W1965127680 hasPublicationYear "2006" @default.
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