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• W1965133274 abstract "No AccessJournal of UrologyAdult Urology1 Feb 2015Utility of Biomarkers in the Prediction of Oncologic Outcome after Radical Cystectomy for Squamous Cell Carcinoma Ramy F. Youssef, Friedrich-Carl von Rundstedt, Payal Kapur, Ahmed Mosbah, Hassan Abol-Enein, Mohamed Ghoneim, and Yair Lotan Ramy F. YoussefRamy F. Youssef Department of Urology, University of California-Irvine, Irvine, California Department of Urology and Nephrology Center, Mansoura University, Mansoura, Egypt Equal study contribution. More articles by this author , Friedrich-Carl von RundstedtFriedrich-Carl von Rundstedt Department of Helios Klinikum Wuppertal, University Witten-Herdecke, Germany Department of Urology, Baylor College of Medicine, Houston, Texas Equal study contribution. More articles by this author , Payal KapurPayal Kapur Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas More articles by this author , Ahmed MosbahAhmed Mosbah Department of Urology and Nephrology Center, Mansoura University, Mansoura, Egypt More articles by this author , Hassan Abol-EneinHassan Abol-Enein Department of Urology and Nephrology Center, Mansoura University, Mansoura, Egypt More articles by this author , Mohamed GhoneimMohamed Ghoneim Department of Urology and Nephrology Center, Mansoura University, Mansoura, Egypt More articles by this author , and Yair LotanYair Lotan Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.08.109AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the association of multiple biomarkers with clinical outcomes in patients treated with radical cystectomy for squamous cell carcinoma of the bladder to identify the best prognostic panel of markers. Materials and Methods: Immunohistochemistry for 14 biomarkers was performed on tissue microarray sections of 151 radical cystectomy specimens showing squamous cell carcinoma. Biomarker alterations, pathological features and oncologic outcomes were evaluated. The panel of biomarkers that best predicted the oncologic outcome was determined. Outcomes were stratified based on a prognostic score according to the number of altered biomarkers. The accuracy of oncologic outcome prediction was evaluated by ROC curves. Results: The study included 151 patients. Pathological stage was T2 in 50%, T3 in 38%, T1 in 6% and T4 in 6% of patients. Median followup was 63.2 months. The best prognostic panel of markers included COX-2, FGF-2, p53, Bax and EGFR. On multivariate Cox regression analysis a prognostic score based on marker alterations was an independent predictor of intermediate and high risk of disease recurrence (HR 3.2, p = 0.008 and HR 15.5, p ≤0.001) and bladder cancer specific mortality (HR 5.2, p = 0.009 and HR 19.4, p ≤0.001, respectively). A multivariate prognostic model incorporating the prognostic score demonstrated significantly better performance to predict the outcome compared to clinicopathological parameters only (0.78 vs 0.64). Conclusions: Biomarkers have significant potential to predict the outcome of radical cystectomy for squamous cell carcinoma. An increased number of altered markers may identify patients at high risk who might benefit from multimodal treatment approaches. References 1 : Squamous cell carcinogenesis and squamous cell carcinoma of the urinary bladder: a contemporary review with focus on nonbilharzial squamous cell carcinoma. Urol Oncol2013; 32: e11. 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Google Scholar © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 2February 2015Page: 451-456Supplementary Materials Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.Keywordscystectomycarcinomabiological markersschistosomiasisurinary bladdersquamous cellMetricsAuthor Information Ramy F. Youssef Department of Urology, University of California-Irvine, Irvine, California Department of Urology and Nephrology Center, Mansoura University, Mansoura, Egypt Equal study contribution. More articles by this author Friedrich-Carl von Rundstedt Department of Helios Klinikum Wuppertal, University Witten-Herdecke, Germany Department of Urology, Baylor College of Medicine, Houston, Texas Equal study contribution. More articles by this author Payal Kapur Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas More articles by this author Ahmed Mosbah Department of Urology and Nephrology Center, Mansoura University, Mansoura, Egypt More articles by this author Hassan Abol-Enein Department of Urology and Nephrology Center, Mansoura University, Mansoura, Egypt More articles by this author Mohamed Ghoneim Department of Urology and Nephrology Center, Mansoura University, Mansoura, Egypt More articles by this author Yair Lotan Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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