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• W1965137169 abstract "Chitosan and its derivative water soluble Chitosan oligosaccharide are used in a variety of applications in pharmaceutical preparations. In this study, 2 wild (ATCC 15729 and PAO1) and 2 mutant strains (PT121 and PT149) of P. aeruginosa are investigated for drug-drug interactions in vitro. 10 antimicrobial agents (antibiotics) are combined with different degree of deacetylated Chitosans and Chitosan oligosaccharide. All the chitosans show synergistic activity with sulfamethoxazole, a sulfonamide antimicrobial agent. It is interesting to observe that the MIC value for the MexEF-OprN overexpressing mutant strain of P. aeruginosa is 5 fold higher than the other strains under investigation suggesting a possible role of this efflux pump in Sulfamethoxazole efflux. The findings suggest on the use of chitosans as enhancing agent in combination with antibiotics in pharmaceutical preparations." @default.
• W1965137169 created "2016-06-24" @default.
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• W1965137169 date "2009-01-01" @default.
• W1965137169 modified "2023-10-12" @default.
• W1965137169 title "Activity of Chitosans in combination with antibiotics in <i>Pseudomonas aeruginosa</i>" @default.
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• W1965137169 doi "https://doi.org/10.7150/ijbs.5.153" @default.
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