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• W1965149342 abstract "Glycine-extended gastrin (G-Gly) is produced by colon cancers and has growth promoting and anti-apoptotic effects in the colonic epithelium. We have examined the anti-apoptotic effects of G-Gly and the signal transduction pathways involved. G-Gly stimulated HT-29 cell proliferation in a concentration dependent manner and inhibited serum-starvation and celecoxib-induced apoptosis. Inhibition of signalling via c-Jun NH2-terminal kinase (JNK) with SP600125 or PI3-kinase/Akt with LY294002 abolished the effects of G-Gly. G-Gly significantly increased phosphorylation of both JNK and Akt. The JAK2 inhibitor AG490 abolished the anti-apoptotic effect of G-Gly and inhibited phosphorylation of Akt but not of JNK. G-Gly stimulated tyrosine phosphorylation of JAK2. G-Gly-increased activation of AP-1 was JNK-dependant and activation of STAT3 was JAK2-dependant. We conclude that G-Gly promotes growth and inhibits apoptosis in colon cancer cells. These effects are mediated via the JAK2, PI3-kinase/Akt and JNK pathways. Activation of JAK2 is upstream of Akt but not of JNK." @default.
• W1965149342 created "2016-06-24" @default.
• W1965149342 creator A5009689476 @default.
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• W1965149342 date "2006-03-01" @default.
• W1965149342 modified "2023-10-17" @default.
• W1965149342 title "Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways" @default.
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• W1965149342 doi "https://doi.org/10.1016/j.mce.2005.12.050" @default.
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