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- W1965156902 abstract "Abstract Clearly, there is ample evidence for the importance of protein binding on the in vivo effectiveness of antimicrobial agents. Although protein binding may have a minimal influence on activity for bacteria that are exquisitely sensitive, it can become a limiting factor when dealing with moderate or marginally sensitive organisms. Protein binding also can limit the rate of penetration of antibiotics into extracellular fluids and tissues. Future studies should be focusing on the correlation of efficacy with area under the curve of free antibiotic as suggested by Barriere et al. This could be facilitated by the recent work by Leggett et al on the use of serum ultrafiltrates. It is in this manner that the pharmacokinetics and pharmacodynamics of antimicrobial agents can best be correlated with clinical outcome." @default.
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- W1965156902 date "1990-04-01" @default.
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- W1965156902 title "The influence of protein binding on in vivo effectiveness of antimicrobial agents" @default.
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- W1965156902 doi "https://doi.org/10.1016/0278-2316(90)90073-o" @default.
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