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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965157424> ?p ?o ?g. }

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• W1965157424 abstract "The first total synthesis of (+)-7-bromotrypargine, a β-carboline alkaloid from Ancornia sp. is reported. The synthesis proceeds in 9 steps, 8 steps longest linear sequence, in 36.9% overall yield. Biological characterization found that (+)-7-bromotrypargine is an H(3) antagonist, and a selective inhibitor of DAT and NET, without inhibiting SERT. Moreover, unlike electron rich congeners, (+)-7-bromotrypargine is not cytotoxic, and thus represents an attractive starting point for chemical optimization; therefore, we piloted a number of chemistries for the synthesis of unnatural analogs." @default.
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• W1965157424 date "2011-08-18" @default.
• W1965157424 modified "2023-09-24" @default.
• W1965157424 title "Total Synthesis of (+)-7-Bromotrypargine and Unnatural Analogues: Biological Evaluation Uncovers Activity at CNS Targets of Therapeutic Relevance" @default.
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• W1965157424 doi "https://doi.org/10.1021/cn200075n" @default.
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