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• W1965170368 abstract "Mitochondrial cytochrome P450 systems are an indispensable component of mammalian steroid biosynthesis; they catalyze regio- and stereo-specific steroid hydroxylations and consist of three protein entities: adrenodoxin reductase (AdR), adrenodoxin (Adx), and a mitochondrial cytochrome P450 enzyme, e.g., CYP11A1 (P450 side chain cleavage, P450scc). It is known that the latter two are able to generate reactive oxygen species (ROS) in vitro. In this study, we investigated whether this ROS generation also occurs in vivo and, if so, whether it leads to the induction of apoptosis. We found that overexpression of either human or bovine Adx causes a significant loss of viability in 11 different cell lines. This loss of viability does not depend on the presence of the tumor suppressor protein p53. Transient overexpression of human Adx in HCT116 cells leads to ROS production, to a disruption of the mitochondrial transmembrane potential (ΔΨ), to cytochrome c release from the mitochondria, and to caspase activation. In contrast, the effect of transient overexpression of human CYP11A1 on cell viability varies in different cell lines, with some being sensitive and others not. We conclude that mitochondrial cytochrome P450 systems are a source of mitochondrial ROS production and can play a role in the induction of mitochondrial apoptosis." @default.
• W1965170368 created "2016-06-24" @default.
• W1965170368 creator A5025018832 @default.
• W1965170368 creator A5039695857 @default.
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• W1965170368 date "2005-01-01" @default.
• W1965170368 modified "2023-09-24" @default.
• W1965170368 title "Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria" @default.
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• W1965170368 doi "https://doi.org/10.1515/bc.2005.054" @default.
• W1965170368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15927889" @default.
• W1965170368 hasPublicationYear "2005" @default.
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