FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965173834> ?p ?o ?g. }

• W1965173834 endingPage "1330" @default.
• W1965173834 startingPage "1318" @default.
• W1965173834 abstract "Birdsong is a learned vocal behaviour that requires intact hearing for its development in juveniles and for its maintenance during adulthood. However, the functional organization of the brain circuits involved in the perceptual processing of song has remained obscure. Here we provide evidence that GABAergic mechanisms are an important component of these circuits and participate in the auditory processing of birdsong. We first cloned a zebra finch homologue of the gene encoding the 65-kDa isoform of glutamic acid decarboxylase (zGAD-65), a specific GABAergic marker, and conducted an expression analysis by in situ hybridization to identify GABAergic cells and to map their distribution throughout auditory telencephalic areas. The results showed that field L2, the caudomedial nidopallium (NCM) and the caudomedial mesopallium (CMM) contain a high number of GABAergic cells. Using patch-clamp brain slice recordings, we found abundant GABAergic mIPSCs in NCM. Pharmacological antagonism of mIPSCs induced large EPSC bursts, suggesting that tonic inhibition helps to stabilize NCM against runaway excitation via activation of GABA-A receptors. Next, using double fluorescence in situ hybridization and double immunocytochemical labelling, we demonstrated that large numbers of GABAergic cells in NCM and CMM show inducible expression of the transcriptional regulator ZENK in response to song auditory stimulation. These data provide direct evidence that GABAergic neurons in auditory brain regions are activated by song stimulation. Altogether, our results suggest that GABAergic mechanisms participate in auditory processing and perception, and might contribute to the memorization of birdsong." @default.
• W1965173834 created "2016-06-24" @default.
• W1965173834 creator A5000321889 @default.
• W1965173834 creator A5038966561 @default.
• W1965173834 creator A5068469745 @default.
• W1965173834 creator A5068496162 @default.
• W1965173834 creator A5076890850 @default.
• W1965173834 creator A5079560411 @default.
• W1965173834 creator A5086214846 @default.
• W1965173834 date "2004-09-01" @default.
• W1965173834 modified "2023-10-11" @default.
• W1965173834 title "GABAergic neurons participate in the brain's response to birdsong auditory stimulation" @default.
• W1965173834 cites W1501153304 @default.
• W1965173834 cites W1506317751 @default.
• W1965173834 cites W1512090235 @default.
• W1965173834 cites W1563662869 @default.
• W1965173834 cites W1572940307 @default.
• W1965173834 cites W1591075818 @default.
• W1965173834 cites W1601502075 @default.
• W1965173834 cites W1655264210 @default.
• W1965173834 cites W1758735213 @default.
• W1965173834 cites W1869876350 @default.
• W1965173834 cites W1931794205 @default.
• W1965173834 cites W1968989849 @default.
• W1965173834 cites W1974195095 @default.
• W1965173834 cites W1974589042 @default.
• W1965173834 cites W1978759815 @default.
• W1965173834 cites W1981008315 @default.
• W1965173834 cites W1983808766 @default.
• W1965173834 cites W1985384458 @default.
• W1965173834 cites W1986816308 @default.
• W1965173834 cites W1991563283 @default.
• W1965173834 cites W1992772167 @default.
• W1965173834 cites W1993770350 @default.
• W1965173834 cites W1999713747 @default.
• W1965173834 cites W2002643773 @default.
• W1965173834 cites W2004174427 @default.
• W1965173834 cites W2012065226 @default.
• W1965173834 cites W2014884863 @default.
• W1965173834 cites W2016402687 @default.
• W1965173834 cites W2027317959 @default.
• W1965173834 cites W2028546554 @default.
• W1965173834 cites W2030421765 @default.
• W1965173834 cites W2035635750 @default.
• W1965173834 cites W2040734004 @default.
• W1965173834 cites W2042532027 @default.
• W1965173834 cites W2042999375 @default.
• W1965173834 cites W2050778300 @default.
• W1965173834 cites W2053206809 @default.
• W1965173834 cites W2054407428 @default.
• W1965173834 cites W2058177325 @default.
• W1965173834 cites W2058951835 @default.
• W1965173834 cites W2065153385 @default.
• W1965173834 cites W2065357806 @default.
• W1965173834 cites W2068987412 @default.
• W1965173834 cites W2070494411 @default.
• W1965173834 cites W2070575950 @default.
• W1965173834 cites W2072573580 @default.
• W1965173834 cites W2072722219 @default.
• W1965173834 cites W2077212686 @default.
• W1965173834 cites W2078922871 @default.
• W1965173834 cites W2079360703 @default.
• W1965173834 cites W2079415701 @default.
• W1965173834 cites W2081408076 @default.
• W1965173834 cites W2081849477 @default.
• W1965173834 cites W2094420852 @default.
• W1965173834 cites W2098659298 @default.
• W1965173834 cites W2115064581 @default.
• W1965173834 cites W2116286046 @default.
• W1965173834 cites W2120087253 @default.
• W1965173834 cites W2122211400 @default.
• W1965173834 cites W2134812217 @default.
• W1965173834 cites W2141280215 @default.
• W1965173834 cites W2141449738 @default.
• W1965173834 cites W2141716990 @default.
• W1965173834 cites W2151516651 @default.
• W1965173834 cites W2153014187 @default.
• W1965173834 cites W2154382930 @default.
• W1965173834 cites W2157319045 @default.
• W1965173834 cites W2162356040 @default.
• W1965173834 cites W2171932770 @default.
• W1965173834 cites W2207426483 @default.
• W1965173834 cites W2235552820 @default.
• W1965173834 cites W2423617197 @default.
• W1965173834 cites W2428967822 @default.
• W1965173834 cites W2493727396 @default.
• W1965173834 cites W4230640845 @default.
• W1965173834 cites W4248085427 @default.
• W1965173834 cites W4252759246 @default.
• W1965173834 cites W4255978131 @default.
• W1965173834 doi "https://doi.org/10.1111/j.1460-9568.2004.03585.x" @default.
• W1965173834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15341603" @default.
• W1965173834 hasPublicationYear "2004" @default.
• W1965173834 type Work @default.
• W1965173834 sameAs 1965173834 @default.
• W1965173834 citedByCount "61" @default.
• W1965173834 countsByYear W19651738342012 @default.
• W1965173834 countsByYear W19651738342013 @default.

• next