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- W1965188957 abstract "By controlling mitochondrial membrane permeability, the Bcl-2 family of proteins plays a crucial role in the regulation of cell death. Members of this family are functionally categorized as either pro- or anti-apoptotic based on their ability to promote or inhibit mitochondrial-dependent cell death signals. The critical role of Bcl-2 family proteins in human diseases has made them the focus of intense research by the pharmaceutical industry and academia. Anti-apoptotic Bcl-2 homologues have been widely explored as potential therapeutic targets for anticancer therapy through the development of nucleic-acid and peptide-based inhibitory molecules. Recently, strategies for the development of peptides or polypeptides derived from specific Bcl-2 family members have also been devised. This paper provides a brief review of the most recent patents that have been published relating to this area." @default.
- W1965188957 created "2016-06-24" @default.
- W1965188957 creator A5002553667 @default.
- W1965188957 date "2009-06-01" @default.
- W1965188957 modified "2023-09-26" @default.
- W1965188957 title "Novel Genetic and Peptide-Based Strategies Targeting the Bcl-2 Family, an Update" @default.
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- W1965188957 doi "https://doi.org/10.2174/187221509788654160" @default.
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