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• W1965194519 endingPage "e3249" @default.
• W1965194519 startingPage "e3249" @default.
• W1965194519 abstract "Background The study of P element repression in Drosophila melanogaster led to the discovery of the telomeric Trans-Silencing Effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin (Telomeric Associated Sequences, “TAS”) has the capacity to repress in trans, in the female germline, a homologous P-lacZ transgene located in euchromatin. TSE can show variegation in ovaries, displays a maternal effect as well as an epigenetic transmission through meiosis and involves heterochromatin and RNA silencing pathways. Principal Findings Here, we analyze phenotypic and genetic properties of TSE. We report that TSE does not occur in the soma at the adult stage, but appears restricted to the female germline. It is detectable during development at the third instar larvae where it presents the same tissue specificity and maternal effect as in adults. Transgenes located in TAS at the telomeres of the main chromosomes can be silencers which in each case show the maternal effect. Silencers located at non-homologous telomeres functionally interact since they stimulate each other via the maternally-transmitted component. All germinally-expressed euchromatic transgenes tested, located on all major chromosomes, were found to be repressed by a telomeric silencer: thus we detected no TSE escaper. The presence of the euchromatic target transgene is not necessary to establish the maternal inheritance of TSE, responsible for its epigenetic behavior. A single telomeric silencer locus can simultaneously repress two P-lacZ targets located on different chromosomal arms. Conclusions and Significance Therefore TSE appears to be a widespread phenomenon which can involve different telomeres and work across the genome. It can explain the P cytotype establishment by telomeric P elements in natural Drosophila populations." @default.
• W1965194519 created "2016-06-24" @default.
• W1965194519 creator A5012998139 @default.
• W1965194519 creator A5015130894 @default.
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• W1965194519 creator A5072398454 @default.
• W1965194519 date "2008-09-22" @default.
• W1965194519 modified "2023-10-16" @default.
• W1965194519 title "Telomeric Trans-Silencing in Drosophila melanogaster: Tissue Specificity, Development and Functional Interactions between Non-Homologous Telomeres" @default.
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• W1965194519 doi "https://doi.org/10.1371/journal.pone.0003249" @default.
• W1965194519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2547894" @default.
• W1965194519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18813361" @default.
• W1965194519 hasPublicationYear "2008" @default.
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