FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965196624> ?p ?o ?g. }

• W1965196624 abstract "Despite setbacks to the approval of new medications for the treatment of irritable bowel syndrome, interim guidelines on endpoints for irritable bowel syndrome (IBS) trials have enhanced interest as new targets for medical therapy are proposed based on novel mechanisms or chemical entities.To review the approved lubiprostone, two targets that are not meeting expectations (tachykinins and corticotrophin-releasing hormone), the efficacy and safety of new 5-HT(4) agonists, intestinal secretagogues (chloride channel activators, and guanylate cyclase-C agonists), bile acid modulation, anti-inflammatory agents and visceral analgesics.Review of selected articles based on PubMed search and clinically relevant information on mechanism of action, safety, pharmacodynamics and efficacy.The spectrum of peripheral targets of medical therapy addresses chiefly the bowel dysfunction of IBS and these effects are associated with pain relief. The pivotal mechanisms responsible for the abdominal pain or visceral sensation in IBS are unknown. The new 5-HT(4) agonists are more specific than older agents and show cardiovascular safety to date. Secretory agents have high specificity, low bioavailability and high efficacy. The potential risks of agents 'borrowed' from other indications (such as hyperlipidaemia, inflammatory bowel disease or somatic pain) deserve further study.There is reason for optimism in medical treatment of IBS with a spectrum of agents to treat bowel dysfunction. However, visceral analgesic treatments are still suboptimal." @default.
• W1965196624 created "2016-06-24" @default.
• W1965196624 creator A5001729912 @default.
• W1965196624 date "2010-01-01" @default.
• W1965196624 modified "2023-09-24" @default.
• W1965196624 title "Review article: new receptor targets for medical therapy in irritable bowel syndrome" @default.
• W1965196624 cites W1491518420 @default.
• W1965196624 cites W1501397556 @default.
• W1965196624 cites W1543394229 @default.
• W1965196624 cites W1544394016 @default.
• W1965196624 cites W1965194352 @default.
• W1965196624 cites W1967300240 @default.
• W1965196624 cites W1967359512 @default.
• W1965196624 cites W1971627211 @default.
• W1965196624 cites W1973915683 @default.
• W1965196624 cites W1976068711 @default.
• W1965196624 cites W1984345984 @default.
• W1965196624 cites W1987817571 @default.
• W1965196624 cites W1989598346 @default.
• W1965196624 cites W2001537992 @default.
• W1965196624 cites W2006221267 @default.
• W1965196624 cites W2006346166 @default.
• W1965196624 cites W2007133271 @default.
• W1965196624 cites W2008569836 @default.
• W1965196624 cites W2016630352 @default.
• W1965196624 cites W2017232891 @default.
• W1965196624 cites W2019788610 @default.
• W1965196624 cites W2028729281 @default.
• W1965196624 cites W2032519173 @default.
• W1965196624 cites W2034036187 @default.
• W1965196624 cites W2039342085 @default.
• W1965196624 cites W2040038239 @default.
• W1965196624 cites W2042615016 @default.
• W1965196624 cites W2042968286 @default.
• W1965196624 cites W2046189497 @default.
• W1965196624 cites W2047798592 @default.
• W1965196624 cites W2048924302 @default.
• W1965196624 cites W2049248578 @default.
• W1965196624 cites W2053598582 @default.
• W1965196624 cites W2058976148 @default.
• W1965196624 cites W2060241341 @default.
• W1965196624 cites W2064433763 @default.
• W1965196624 cites W2064683282 @default.
• W1965196624 cites W2067275750 @default.
• W1965196624 cites W2068454300 @default.
• W1965196624 cites W2076183293 @default.
• W1965196624 cites W2078020393 @default.
• W1965196624 cites W2078260689 @default.
• W1965196624 cites W2080734760 @default.
• W1965196624 cites W2084045647 @default.
• W1965196624 cites W2085068901 @default.
• W1965196624 cites W2088344246 @default.
• W1965196624 cites W2088698613 @default.
• W1965196624 cites W2092414646 @default.
• W1965196624 cites W2093366809 @default.
• W1965196624 cites W2096261713 @default.
• W1965196624 cites W2098919480 @default.
• W1965196624 cites W2099165053 @default.
• W1965196624 cites W2112418861 @default.
• W1965196624 cites W2114251971 @default.
• W1965196624 cites W2114567997 @default.
• W1965196624 cites W2116955650 @default.
• W1965196624 cites W2117456715 @default.
• W1965196624 cites W2128077096 @default.
• W1965196624 cites W2136444635 @default.
• W1965196624 cites W2137002278 @default.
• W1965196624 cites W2155674326 @default.
• W1965196624 cites W2157275283 @default.
• W1965196624 cites W2162989797 @default.
• W1965196624 cites W2165751816 @default.
• W1965196624 cites W2168967776 @default.
• W1965196624 cites W2170372540 @default.
• W1965196624 cites W2170752901 @default.
• W1965196624 cites W2978177469 @default.
• W1965196624 cites W2978809217 @default.
• W1965196624 doi "https://doi.org/10.1111/j.1365-2036.2009.04153.x" @default.
• W1965196624 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2896496" @default.
• W1965196624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19785622" @default.
• W1965196624 hasPublicationYear "2010" @default.
• W1965196624 type Work @default.
• W1965196624 sameAs 1965196624 @default.
• W1965196624 citedByCount "50" @default.
• W1965196624 countsByYear W19651966242012 @default.
• W1965196624 countsByYear W19651966242013 @default.
• W1965196624 countsByYear W19651966242014 @default.
• W1965196624 countsByYear W19651966242015 @default.
• W1965196624 countsByYear W19651966242016 @default.
• W1965196624 countsByYear W19651966242017 @default.
• W1965196624 countsByYear W19651966242020 @default.
• W1965196624 countsByYear W19651966242021 @default.
• W1965196624 crossrefType "journal-article" @default.
• W1965196624 hasAuthorship W1965196624A5001729912 @default.
• W1965196624 hasBestOaLocation W19651966241 @default.
• W1965196624 hasConcept C126322002 @default.
• W1965196624 hasConcept C166957645 @default.
• W1965196624 hasConcept C177713679 @default.
• W1965196624 hasConcept C2776957806 @default.
• W1965196624 hasConcept C2778271842 @default.
• W1965196624 hasConcept C2781093762 @default.
• W1965196624 hasConcept C2781112942 @default.

• next