FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965200033> ?p ?o ?g. }

• W1965200033 endingPage "e113100" @default.
• W1965200033 startingPage "e113100" @default.
• W1965200033 abstract "Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in children and is responsible for as many as 199,000 childhood deaths annually worldwide. To support the development of viral therapeutics and vaccines for RSV, a human adult experimental infection model has been established. In this report, we describe the provenance and sequence of RSV Memphis-37, the low-passage clinical isolate used for the model's reproducible, safe, experimental infections of healthy, adult volunteers. The predicted amino acid sequences for major proteins of Memphis-37 are compared to nine other RSV A and B amino acid sequences to examine sites of vaccine, therapeutic, and pathophysiologic interest. Human T- cell epitope sequences previously defined by in vitro studies were observed to be closely matched between Memphis-37 and the laboratory strain RSV A2. Memphis-37 sequences provide baseline data with which to assess: (i) virus heterogeneity that may be evident following virus infection/transmission, (ii) the efficacy of candidate RSV vaccines and therapeutics in the experimental infection model, and (iii) the potential emergence of escape mutants as a consequence of experimental drug treatments. Memphis-37 is a valuable tool for pre-clinical research, and to expedite the clinical development of vaccines, therapeutic immunomodulatory agents, and other antiviral drug strategies for the protection of vulnerable populations against RSV disease." @default.
• W1965200033 created "2016-06-24" @default.
• W1965200033 creator A5003266453 @default.
• W1965200033 creator A5010114982 @default.
• W1965200033 creator A5031163541 @default.
• W1965200033 creator A5036771694 @default.
• W1965200033 creator A5044380425 @default.
• W1965200033 creator A5044998506 @default.
• W1965200033 creator A5051793462 @default.
• W1965200033 creator A5054946368 @default.
• W1965200033 creator A5075332485 @default.
• W1965200033 date "2014-11-21" @default.
• W1965200033 modified "2023-10-10" @default.
• W1965200033 title "Respiratory Syncytial Virus Human Experimental Infection Model: Provenance, Production, and Sequence of Low-Passaged Memphis-37 Challenge Virus" @default.
• W1965200033 cites W1587614700 @default.
• W1965200033 cites W1660139323 @default.
• W1965200033 cites W1857608076 @default.
• W1965200033 cites W1970650250 @default.
• W1965200033 cites W1990356930 @default.
• W1965200033 cites W1995394477 @default.
• W1965200033 cites W1999228474 @default.
• W1965200033 cites W1999561390 @default.
• W1965200033 cites W2004970207 @default.
• W1965200033 cites W2022993968 @default.
• W1965200033 cites W2026055515 @default.
• W1965200033 cites W2026786690 @default.
• W1965200033 cites W2028941141 @default.
• W1965200033 cites W2031544594 @default.
• W1965200033 cites W2033278608 @default.
• W1965200033 cites W2034579657 @default.
• W1965200033 cites W2043056303 @default.
• W1965200033 cites W2044100991 @default.
• W1965200033 cites W2046263350 @default.
• W1965200033 cites W2051874642 @default.
• W1965200033 cites W2065401799 @default.
• W1965200033 cites W2069947510 @default.
• W1965200033 cites W2077096621 @default.
• W1965200033 cites W2080800625 @default.
• W1965200033 cites W2098871417 @default.
• W1965200033 cites W2101403791 @default.
• W1965200033 cites W2103098366 @default.
• W1965200033 cites W2109831018 @default.
• W1965200033 cites W2113980943 @default.
• W1965200033 cites W2120949068 @default.
• W1965200033 cites W2122575257 @default.
• W1965200033 cites W2123834730 @default.
• W1965200033 cites W2129415799 @default.
• W1965200033 cites W2131354424 @default.
• W1965200033 cites W2149400231 @default.
• W1965200033 cites W2159482780 @default.
• W1965200033 cites W2163986700 @default.
• W1965200033 cites W2165688089 @default.
• W1965200033 cites W2168421996 @default.
• W1965200033 cites W2202851436 @default.
• W1965200033 cites W4292315834 @default.
• W1965200033 doi "https://doi.org/10.1371/journal.pone.0113100" @default.
• W1965200033 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4240712" @default.
• W1965200033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25415360" @default.
• W1965200033 hasPublicationYear "2014" @default.
• W1965200033 type Work @default.
• W1965200033 sameAs 1965200033 @default.
• W1965200033 citedByCount "30" @default.
• W1965200033 countsByYear W19652000332015 @default.
• W1965200033 countsByYear W19652000332017 @default.
• W1965200033 countsByYear W19652000332018 @default.
• W1965200033 countsByYear W19652000332019 @default.
• W1965200033 countsByYear W19652000332020 @default.
• W1965200033 countsByYear W19652000332021 @default.
• W1965200033 countsByYear W19652000332022 @default.
• W1965200033 countsByYear W19652000332023 @default.
• W1965200033 crossrefType "journal-article" @default.
• W1965200033 hasAuthorship W1965200033A5003266453 @default.
• W1965200033 hasAuthorship W1965200033A5010114982 @default.
• W1965200033 hasAuthorship W1965200033A5031163541 @default.
• W1965200033 hasAuthorship W1965200033A5036771694 @default.
• W1965200033 hasAuthorship W1965200033A5044380425 @default.
• W1965200033 hasAuthorship W1965200033A5044998506 @default.
• W1965200033 hasAuthorship W1965200033A5051793462 @default.
• W1965200033 hasAuthorship W1965200033A5054946368 @default.
• W1965200033 hasAuthorship W1965200033A5075332485 @default.
• W1965200033 hasBestOaLocation W19652000331 @default.
• W1965200033 hasConcept C159047783 @default.
• W1965200033 hasConcept C159654299 @default.
• W1965200033 hasConcept C195616568 @default.
• W1965200033 hasConcept C203014093 @default.
• W1965200033 hasConcept C2522874641 @default.
• W1965200033 hasConcept C2778987988 @default.
• W1965200033 hasConcept C59822182 @default.
• W1965200033 hasConcept C86803240 @default.
• W1965200033 hasConceptScore W1965200033C159047783 @default.
• W1965200033 hasConceptScore W1965200033C159654299 @default.
• W1965200033 hasConceptScore W1965200033C195616568 @default.
• W1965200033 hasConceptScore W1965200033C203014093 @default.
• W1965200033 hasConceptScore W1965200033C2522874641 @default.
• W1965200033 hasConceptScore W1965200033C2778987988 @default.
• W1965200033 hasConceptScore W1965200033C59822182 @default.
• W1965200033 hasConceptScore W1965200033C86803240 @default.
• W1965200033 hasIssue "11" @default.

• next