Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965216998> ?p ?o ?g. }
- W1965216998 endingPage "e22691" @default.
- W1965216998 startingPage "e22691" @default.
- W1965216998 abstract "Trefoil factors are essential healing initiators participating in mucosal reconstitution and tissue morphogenesis, especially on the surfaces of the gastrointestinal tract. This family has been cloned and characterized predominantly from mammals and amphibians. Avian species ingest stone and grit to help digest food, which may expose their gut to severe physical conditions. To further the understanding of the function of the TFF gene family across species, we undertook this research to clone, sequence, and characterize the spatio-temporal expression patterns of chicken TFF2 (ChTFF2) cDNA. Bioinformatics analysis of the promoter region and deduced amino acid sequence demonstrated that ChTFF2 contained unique characteristics; specifically the chicken promoter has multiple start sites and the protein contains a series of Lys-Lys-Val repeats. Unlike mammals, where TFF2 is detected primarily in the stomach, and occasionally in the proximal duodenum, chicken TFF2 transcripts are found throughout the gastrointestinal tract, with major expression sites in the glandular and muscular stomach as well as evident expression in the colon, small intestine, cecal tonsil and crop. Temporal analysis of intestinal ChTFF2 transcripts by quantitative RT-PCR showed high levels in embryos and a trend of constant expression during embryonic and post-hatch development, with a reduction occurring around hatch. Phylogenetic analysis highlighted the conservation of TFF proteins and functional divergence of trefoil domains, which suggest a transitional role in the bird during evolution." @default.
- W1965216998 created "2016-06-24" @default.
- W1965216998 creator A5033462949 @default.
- W1965216998 creator A5081678793 @default.
- W1965216998 creator A5090225516 @default.
- W1965216998 date "2011-07-29" @default.
- W1965216998 modified "2023-09-26" @default.
- W1965216998 title "Evolution of Trefoil Factor(s): Genetic and Spatio-Temporal Expression of Trefoil Factor 2 in the Chicken (Gallus Gallus Domesticus)" @default.
- W1965216998 cites W1976162686 @default.
- W1965216998 cites W1978413957 @default.
- W1965216998 cites W1982282184 @default.
- W1965216998 cites W1986913452 @default.
- W1965216998 cites W1989552980 @default.
- W1965216998 cites W1999824352 @default.
- W1965216998 cites W2003588449 @default.
- W1965216998 cites W2005803469 @default.
- W1965216998 cites W2011327648 @default.
- W1965216998 cites W2013954729 @default.
- W1965216998 cites W2017761896 @default.
- W1965216998 cites W2023446660 @default.
- W1965216998 cites W2031546590 @default.
- W1965216998 cites W2036224430 @default.
- W1965216998 cites W2043620021 @default.
- W1965216998 cites W2053681448 @default.
- W1965216998 cites W2058246513 @default.
- W1965216998 cites W2061149137 @default.
- W1965216998 cites W2064346829 @default.
- W1965216998 cites W2082578223 @default.
- W1965216998 cites W2087635014 @default.
- W1965216998 cites W2088401080 @default.
- W1965216998 cites W2088975029 @default.
- W1965216998 cites W2092414509 @default.
- W1965216998 cites W2156971181 @default.
- W1965216998 cites W2165762437 @default.
- W1965216998 cites W2167786199 @default.
- W1965216998 cites W2171217269 @default.
- W1965216998 cites W2177020680 @default.
- W1965216998 cites W4253199270 @default.
- W1965216998 cites W4256132741 @default.
- W1965216998 cites W79452630 @default.
- W1965216998 doi "https://doi.org/10.1371/journal.pone.0022691" @default.
- W1965216998 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3146476" @default.
- W1965216998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21829480" @default.
- W1965216998 hasPublicationYear "2011" @default.
- W1965216998 type Work @default.
- W1965216998 sameAs 1965216998 @default.
- W1965216998 citedByCount "7" @default.
- W1965216998 countsByYear W19652169982013 @default.
- W1965216998 countsByYear W19652169982014 @default.
- W1965216998 countsByYear W19652169982015 @default.
- W1965216998 countsByYear W19652169982017 @default.
- W1965216998 countsByYear W19652169982019 @default.
- W1965216998 crossrefType "journal-article" @default.
- W1965216998 hasAuthorship W1965216998A5033462949 @default.
- W1965216998 hasAuthorship W1965216998A5081678793 @default.
- W1965216998 hasAuthorship W1965216998A5090225516 @default.
- W1965216998 hasBestOaLocation W19652169981 @default.
- W1965216998 hasConcept C103077935 @default.
- W1965216998 hasConcept C104317684 @default.
- W1965216998 hasConcept C150194340 @default.
- W1965216998 hasConcept C153911025 @default.
- W1965216998 hasConcept C167625842 @default.
- W1965216998 hasConcept C187882448 @default.
- W1965216998 hasConcept C2780512811 @default.
- W1965216998 hasConcept C54355233 @default.
- W1965216998 hasConcept C55493867 @default.
- W1965216998 hasConcept C5911399 @default.
- W1965216998 hasConcept C86803240 @default.
- W1965216998 hasConceptScore W1965216998C103077935 @default.
- W1965216998 hasConceptScore W1965216998C104317684 @default.
- W1965216998 hasConceptScore W1965216998C150194340 @default.
- W1965216998 hasConceptScore W1965216998C153911025 @default.
- W1965216998 hasConceptScore W1965216998C167625842 @default.
- W1965216998 hasConceptScore W1965216998C187882448 @default.
- W1965216998 hasConceptScore W1965216998C2780512811 @default.
- W1965216998 hasConceptScore W1965216998C54355233 @default.
- W1965216998 hasConceptScore W1965216998C55493867 @default.
- W1965216998 hasConceptScore W1965216998C5911399 @default.
- W1965216998 hasConceptScore W1965216998C86803240 @default.
- W1965216998 hasIssue "7" @default.
- W1965216998 hasLocation W19652169981 @default.
- W1965216998 hasLocation W19652169982 @default.
- W1965216998 hasLocation W19652169983 @default.
- W1965216998 hasLocation W19652169984 @default.
- W1965216998 hasLocation W19652169985 @default.
- W1965216998 hasOpenAccess W1965216998 @default.
- W1965216998 hasPrimaryLocation W19652169981 @default.
- W1965216998 hasRelatedWork W1973586570 @default.
- W1965216998 hasRelatedWork W2009966535 @default.
- W1965216998 hasRelatedWork W2015157953 @default.
- W1965216998 hasRelatedWork W2056172754 @default.
- W1965216998 hasRelatedWork W2365238423 @default.
- W1965216998 hasRelatedWork W2375466314 @default.
- W1965216998 hasRelatedWork W2383598698 @default.
- W1965216998 hasRelatedWork W2383713371 @default.
- W1965216998 hasRelatedWork W2386723776 @default.
- W1965216998 hasRelatedWork W4235753716 @default.
- W1965216998 hasVolume "6" @default.